UniProt O60894
Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor (O60894)
Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor (UniProt O60894): 37 experimental structures on GenesisL1, 10 ligands bound, 70 pockets.…
- UniProt
- O60894
- Protein
- Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying…
- Experimental structures
- 37
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 70 · 12 records with a druggable one
Structures
37 records of O60894 in the MolNFT archive: 37 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YX8 | Crystal structure of the extracellular domain of human RAMP1 | x-ray diffraction | A | — | — |
| 2YX8 | Crystal structure of the extracellular domain of human RAMP1 | x-ray diffraction | A | — | — |
| 3N7P | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site… | x-ray diffraction | D, E, F, R | — | — |
| 3N7P | Crystal structure of the ectodomain complex of the cgrp receptor, a class-B GPCR, reveals the site… | x-ray diffraction | D, E, F, R | — | — |
| 3N7R | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site… | x-ray diffraction | C, D | — | — |
| 3N7R | Crystal structure of the ectodomain complex of the cgrp receptor, a class-B GPCR, reveals the site… | x-ray diffraction | C, D | — | — |
| 3N7S | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site… | x-ray diffraction | C, D | — | — |
| 3N7S | Crystal structure of the ectodomain complex of the cgrp receptor, a class-B GPCR, reveals the site… | x-ray diffraction | C, D | — | — |
| 4RWG | Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity CGRP… | x-ray diffraction | A, B, C | — | — |
| 4RWG | Crystal structure of the CLR:RAMP1 extracellular domain heterodimer with bound high affinity cgrp… | x-ray diffraction | A, B, C | — | — |
| 5V6Y | Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity… | x-ray diffraction | A, B, C, D | GLC | 20 (best 0.81) |
| 5V6Y | Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity… | x-ray diffraction | A, B, C, D | NH2, GLC | — |
| 6D1U | Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer in complex with… | x-ray diffraction | A, B, C | NH2, GLC, NA | — |
| 6E3Y | Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor | electron microscopy | E | — | 4 (best 0.76) |
| 6E3Y | Cryo-EM structure of the active, gs-protein complexed, human cgrp receptor | electron microscopy | E | — | — |
| 6UMG | Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor | x-ray diffraction | R, r | — | 3 (best 0.63) |
| 6UMG | Crystal structure of erenumab Fab bound to the extracellular domain of cgrp receptor | x-ray diffraction | R, r | — | — |
| 6ZHO | Crystal structure of a CGRP receptor ectodomain heterodimer with bound high affinity inhibitor | x-ray diffraction | A | GLC, QLQ | 4 (best 0.86) |
| 6ZHO | Crystal structure of a cgrp receptor ectodomain heterodimer with bound high affinity inhibitor | x-ray diffraction | A | GLC, QLQ | — |
| 6ZIS | Crystal structure of a CGRP receptor ectodomain heterodimer with bound high affinity inhibitor | x-ray diffraction | A | GLC, 3N6 | 7 (best 0.82) |
| 6ZIS | Crystal structure of a cgrp receptor ectodomain heterodimer with bound high affinity inhibitor | x-ray diffraction | A | GLC, 3N6 | — |
| 7KNT | CryoEM structure of the apo-CGRP receptor in a detergent micelle | electron microscopy | E | — | 3 (best 0.59) |
| 7KNT | Cryoem structure of the apo-cgrp receptor in a detergent micelle | electron microscopy | E | — | — |
| 7KNU | CryoEM structure of the CGRP receptor with bound CGRP peptide in a detergent micelle | electron microscopy | E | — | 3 (best 0.51) |
| 7KNU | Cryoem structure of the cgrp receptor with bound cgrp peptide in a detergent micelle | electron microscopy | E | — | — |
| 7P0F | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor… | x-ray diffraction | A | GLC, 7IR | 5 (best 0.86) |
| 7P0F | Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor… | x-ray diffraction | A | GLC, 7IR | — |
| 7P0I | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor Compound… | x-ray diffraction | A | GLC, 7IU | 6 (best 0.83) |
| 7P0I | Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor compound… | x-ray diffraction | A | GLC, 7IU | — |
| 7TYF | Human Amylin1 Receptor in complex with Gs and rat amylin peptide | electron microscopy | E | PLM | — |
| 7TYF | Human AMYLIN1 receptor in complex with gs and rat amylin peptide | electron microscopy | E | PLM | — |
| 7TYW | Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide | electron microscopy | E | PLM | — |
| 7TYW | Human AMYLIN1 receptor in complex with gs and salmon calcitonin peptide | electron microscopy | E | PLM | — |
| 8AX5 | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor… | x-ray diffraction | A | GLC, OKU | 7 (best 0.84) |
| 8AX6 | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor… | x-ray diffraction | A | GLC, OP9 | 4 (best 0.85) |
| 9AUC | Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide | electron microscopy | E | PLM | 4 (best 0.64) |
| O60894 | AlphaFold monomer V2.0 prediction for receptor activity-modifying protein 1 (O60894) | — | — | — |
Ligands
- GLC · alpha-D-glucopyranose · in 13 records
- PLM · Palmitic acid · in 5 records
- 3N6 · N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl) carbonyl]pentyl}-3,5-dibromo-nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide · in 2 records
- 7IR · (1S,10R,23E)-12-methyl-10-[(7-methyl-1H-indazol-5-yl) methyl]-15,18,21-trioxa-5,9,12,27,29-pentazapentacyclo[23.5.2.11,4.13,7.028, 31]tetratriaconta-3(33),4,6,23,25(32),26,28(31)-heptaene-8,11,30-trione · in 2 records
- 7IU · (1S,20E)-10-(benzofuran-3-ylmethyl)-12-methyl-15,18-dioxa-5,9,12,24,26-pentazapentacyclo[20.5.2.11,4.13, 7.025,28]hentriaconta-3(30),4,6,20,22(29),23,25(28)-heptaene-8,11,27-trione · in 2 records
- NH2 · Amino group · in 2 records
- QLQ · ~{N}-[(2~{R})-3-(7-methyl-2~{H}-indazol-5-yl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-piperidin-4-yl-1-(4-pyridin-4-ylpiperazin-1-yl)propan-2-yl]amino]propan-2-yl]-2-oxidanylidene-spiro[1~{H}-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide · in 2 records
- NA · Sodium ion · in 1 record
- OKU · (1~{R},10~{R},20~{E})-12-methyl-10-[(7-methyl-2~{H}-indazol-5-yl)methyl]-15,18-dioxa-9,12,24,26-tetrazapentacyclo[20.5.2.1^{1,4}.1^{3,7}.0^{25,28}]hentriaconta-3,5,7(30),20,22,24,28-heptaene-8,11,27-trione · in 1 record
- OP9 · (1~{S},10~{R},20~{E})-12-methyl-10-[(7-methyl-2~{H}-indazol-5-yl)methyl]-15,18-dioxa-9,12,24,26-tetrazapentacyclo[20.5.2.1^{1,4}.1^{3,7}.0^{25,28}]hentriaconta-3(30),4,6,20,22,24,28-heptaene-8,11,27-trione · in 1 record
Experiment against prediction
- 7P0F chain A against the predicted model P0AEX9: TM-score 0.67, RMSD 0.68 Å
- 6ZHO chain A against the predicted model P0AEX9: TM-score 0.64, RMSD 0.69 Å
- 7P0I chain A against the predicted model P0AEX9: TM-score 0.65, RMSD 0.68 Å
- 8AX6 chain A against the predicted model P0AEX9: TM-score 0.65, RMSD 0.55 Å
- 6ZIS chain A against the predicted model P0AEX9: TM-score 0.65, RMSD 0.77 Å
- 8AX5 chain A against the predicted model P0AEX9: TM-score 0.67, RMSD 0.64 Å
- 6ZHO chain A against the predicted model Q16602: TM-score 0.24, RMSD 7.51 Å
- 6ZHO chain A against the predicted model Q16602: TM-score 0.24, RMSD 7.51 Å
- 8AX6 chain A against the predicted model Q16602: TM-score 0.23, RMSD 7.67 Å
- 7P0I chain A against the predicted model Q16602: TM-score 0.23, RMSD 7.64 Å
Elsewhere
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