MolNFT v1 · #136631 · protein
Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs protein complex
5UZ7 · Guanine nucleotide-binding protein G(S) subunit alpha…: “Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric gs protein…”. Electron microscopy, 15 pockets (best druggability 0.85). MolNFT v1…
- PDB
- 5UZ7
- Type
- protein
- Length
- 974 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P30988
- Pockets
- 15 · best druggability 0.85
Structure
electron microscopy · 5 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 185 | 46% helix, 18% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 340 | 8% helix, 39% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 55 | 49% helix, 0% strand | P59768 |
| N | Nanobody 35 | protein | 128 | 5% helix, 43% strand | — |
| R | Calcitonin receptor | protein | 266 | 80% helix, 0% strand | P30988 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 862 | 0.85 | 0.87 | 78 | empty |
| 2 | 988 | 0.75 | 0.78 | 86 | empty |
| 3 | 838 | 0.73 | 0.78 | 59 | empty |
| 4 | 437 | 0.66 | 0.78 | 54 | empty |
| 5 | 50 | 0.65 | 0.94 | 18 | empty |
Interfaces
6 interfaces between chains.
- B–G · 2233 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1550 Ų buried · 19 hydrogen bonds · protein-protein
- A–R · 1061 Ų buried · 7 hydrogen bonds · protein-protein
- A–N · 886 Ų buried · 4 hydrogen bonds · protein-protein
- B–N · 596 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5UZ7 · Volta phase plate cryo-electron microscopy structure of a calcitonin… · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P30988 · AlphaFold monomer V2.0 prediction for calcitonin receptor (P30988) · a predicted model of the same protein · chain R against A, TM-score 0.96
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.88
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P30988
- Elsewhere: RCSB PDB 5UZ7 · PDBe 5UZ7 · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P30988
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