MolNFT v1 · #188571 · protein
Calcitonin receptor in complex with gs and rat amylin peptide, bypass motif
7TYL · Guanine nucleotide-binding protein G(S) subunit alpha…: “Calcitonin receptor in complex with gs and rat amylin peptide, bypass motif”. Electron microscopy, 1 ligand (NH2), 16 pockets (best druggability 0.81). MolNFT v1 #188571 on…
- PDB
- 7TYL
- Type
- protein
- Length
- 1,156 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P12969, P30988
- Ligands
- NH2
- Pockets
- 16 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 228 | 43% helix, 18% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 339 | 8% helix, 42% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 55 | 58% helix, 0% strand | P59768 |
| N | Nanobody 35 | protein | 128 | 7% helix, 45% strand | — |
| P | Amylin peptide | protein | 37 | 38% helix, 0% strand | P12969 |
| R | Calcitonin receptor | protein | 369 | 64% helix, 5% strand | P30988 |
Ligands and binding sites
- NH2 · Amino group · ion · chains P, R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 651 | 0.81 | 0.86 | 56 | empty |
| 2 | 1043 | 0.77 | 0.79 | 63 | empty |
| 3 | 681 | 0.75 | 0.81 | 69 | empty |
| 4 | 1134 | 0.73 | 0.76 | 69 | empty |
| 5 | 567 | 0.71 | 0.80 | 61 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2325 Ų buried · 17 hydrogen bonds · protein-protein
- P–R · 2016 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1538 Ų buried · 21 hydrogen bonds · protein-protein
- A–R · 1125 Ų buried · 7 hydrogen bonds · protein-protein
- A–N · 829 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 7TYL · Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.85
- P30988 · AlphaFold monomer V2.0 prediction for calcitonin receptor (P30988) · a predicted model of the same protein · chain R against A, TM-score 0.82
- P12969 · AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P12969) · a predicted model of the same protein · chain P against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P12969
- Every structure of UniProt P30988
- Elsewhere: RCSB PDB 7TYL · PDBe 7TYL · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P12969 · UniProt P30988
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.