Research workbench

Calcitonin receptor in complex with gs and rat amylin peptide, bypass motif

Analyse Calcitonin receptor in complex with gs and rat amylin peptide, bypass motif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7TYL
Type: protein
Length: 1,156 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
UniProt: P63092, P62873, P59768, P12969, P30988
Ligands: NH2
Pockets: 16 · best druggability 0.81

Structure

electron microscopy · 6 distinct chains · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanine nucleotide-binding protein G(S) subunit alpha isoforms short	protein	228	43% helix, 18% strand	P63092
B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	protein	339	8% helix, 42% strand	P62873
G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	protein	55	58% helix, 0% strand	P59768
N	Nanobody 35	protein	128	7% helix, 45% strand	—
P	Amylin peptide	protein	37	38% helix, 0% strand	P12969
R	Calcitonin receptor	protein	369	64% helix, 5% strand	P30988

Ligands and binding sites

NH2 · Amino group · ion · chains P, R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	651	0.81	0.86	56	empty
2	1043	0.77	0.79	63	empty
3	681	0.75	0.81	69	empty
4	1134	0.73	0.76	69	empty
5	567	0.71	0.80	61	empty

Interfaces

7 interfaces between chains.

B–G · 2325 Å² buried · 17 hydrogen bonds · protein-protein
P–R · 2016 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 1538 Å² buried · 21 hydrogen bonds · protein-protein
A–R · 1125 Å² buried · 7 hydrogen bonds · protein-protein
A–N · 829 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

7TYL · Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif · the same entry in another collection · chain R against R, TM-score 1.00
P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.85
P30988 · AlphaFold monomer V2.0 prediction for calcitonin receptor (P30988) · a predicted model of the same protein · chain R against A, TM-score 0.82
P12969 · AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P12969) · a predicted model of the same protein · chain P against A, TM-score 0.37

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63092
Every structure of UniProt P62873
Every structure of UniProt P59768
Every structure of UniProt P12969
Every structure of UniProt P30988
Elsewhere: RCSB PDB 7TYL · PDBe 7TYL · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P12969 · UniProt P30988

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