Research workbench
Structure of nts-NTSR1-gi complex in lipid nanodisc, canonical state, with ahd
Analyse Structure of nts-NTSR1-gi complex in lipid nanodisc, canonical state, with ahd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7L0Q
- Type
- protein
- Length
- 1,002 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurotensin receptor type 1; Neurotensin; Guanine nucleotide-binding protein G(I) subunit…
- UniProt
- P20789, P20068, P63096, P62873, P63211
- Pockets
- 12 · best druggability 0.79
Structure
electron microscopy · 5 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Neurotensin receptor type 1 | protein | 309 | 74% helix, 3% strand | P20789 |
| D | Neurotensin | protein | 6 | 0% helix, 0% strand | P20068 |
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 337 | 52% helix, 9% strand | P63096 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 311 | 0% helix, 45% strand | P62873 |
| G | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | protein | 39 | 38% helix, 0% strand | P63211 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 921 | 0.79 | 0.81 | 85 | empty |
| 2 | 484 | 0.78 | 0.85 | 48 | empty |
| 3 | 53 | 0.71 | 0.98 | 22 | empty |
| 4 | 141 | 0.59 | 0.84 | 30 | empty |
| 5 | 331 | 0.59 | 0.77 | 31 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1805 Ų buried · 18 hydrogen bonds · protein-protein
- B–G · 1443 Ų buried · 10 hydrogen bonds · protein-protein
- C–A · 1285 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 878 Ų buried · 10 hydrogen bonds · protein-protein
- C–B · 35 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7L0Q · Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, with AHD · the same entry in another collection · chain G against G, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P20789 · AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P20789) · a predicted model of the same protein · chain C against A, TM-score 0.96
- P63211 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain G against A, TM-score 0.79
- P20068 · AlphaFold monomer V2.0 prediction for NEUROTENSIN/NEUROMEDIN N (P20068) · a predicted model of the same protein · chain D against A, TM-score 0.63
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20789
- Every structure of UniProt P20068
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P63211
- Elsewhere: RCSB PDB 7L0Q · PDBe 7L0Q · UniProt P20789 · UniProt P20068 · UniProt P63096 · UniProt P62873 · UniProt P63211
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