UniProt P20789
Neurotensin receptor type 1 (P20789)
Neurotensin receptor type 1 (UniProt P20789), EC 3.2.1.17: 33 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 72 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P20789
- Protein
- Neurotensin receptor type 1
- EC
- 3.2.1.17
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 72 · 15 records with a druggable one
Structures
34 records of P20789 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ZEV | Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion | x-ray diffraction | A, B | — | — |
| 3ZEV | Structure of thermostable agonist-bound neurotensin receptor 1 mutant without lysozyme fusion | x-ray diffraction | A, B | — | — |
| 4BUO | High Resolution Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without… | x-ray diffraction | A, B | — | — |
| 4BUO | High resolution structure of thermostable agonist-bound neurotensin receptor 1 mutant without… | x-ray diffraction | A, B | — | — |
| 4BV0 | High Resolution Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme… | x-ray diffraction | A, B | — | — |
| 4BV0 | High resolution structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme… | x-ray diffraction | A, B | — | — |
| 4BWB | Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion | x-ray diffraction | A, B | — | — |
| 4BWB | Structure of evolved agonist-bound neurotensin receptor 1 mutant without lysozyme fusion | x-ray diffraction | A, B | — | — |
| 4GRV | The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13) | x-ray diffraction | A | — | — |
| 4GRV | The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13) | x-ray diffraction | A | — | — |
| 4XEE | Structure of active-like neurotensin receptor | x-ray diffraction | A | — | — |
| 4XEE | Structure of active-like neurotensin receptor | x-ray diffraction | A | — | — |
| 4XES | Structure of active-like neurotensin receptor | x-ray diffraction | A | — | — |
| 4XES | Structure of active-like neurotensin receptor | x-ray diffraction | A | — | — |
| 5T04 | Structure of constitutively active neurotensin receptor | x-ray diffraction | A | TCE | 3 (best 0.57) |
| 5T04 | Structure of constitutively active neurotensin receptor | x-ray diffraction | A | TCE | — |
| 6YVR | Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13 | x-ray diffraction | AAA, BBB | BNG | 13 (best 0.82) |
| 6Z4S | Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule… | x-ray diffraction | AAA | Q6Q | 3 (best 0.62) |
| 6Z4V | Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with NTS8-13 | x-ray diffraction | AAA | — | 2 (best 0.74) |
| 6Z8N | Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist… | x-ray diffraction | AAA | SR9 | 6 (best 0.77) |
| 6ZA8 | Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist… | x-ray diffraction | AAA | SR5 | 4 (best 0.73) |
| 6ZIN | Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist… | x-ray diffraction | AAA | Q6Q | 2 (best 0.73) |
| 7L0P | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, without AHD | electron microscopy | C | — | 7 (best 0.77) |
| 7L0P | Structure of nts-NTSR1-gi complex in lipid nanodisc, canonical state, without ahd | electron microscopy | C | — | — |
| 7L0Q | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, with AHD | electron microscopy | C | — | 7 (best 0.79) |
| 7L0Q | Structure of nts-NTSR1-gi complex in lipid nanodisc, canonical state, with ahd | electron microscopy | C | — | — |
| 7L0R | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, without AHD | electron microscopy | C | — | 5 (best 0.78) |
| 7L0R | Structure of nts-NTSR1-gi complex in lipid nanodisc, noncanonical state, without ahd | electron microscopy | C | — | — |
| 7L0S | Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, with AHD | electron microscopy | C | — | 5 (best 0.78) |
| 7L0S | Structure of nts-NTSR1-gi complex in lipid nanodisc, noncanonical state, with ahd | electron microscopy | C | — | — |
| 8FMZ | Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator | electron microscopy | A | — | 1 (best 0.69) |
| 8FN0 | CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator | electron microscopy | A | SRW | 5 (best 0.81) |
| 8FN1 | CryoEM structure of Go-coupled NTSR1 | electron microscopy | A | — | 4 (best 0.72) |
| P20789 | AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P20789) | predicted | A | — | 5 (best 0.81) |
Ligands
- Q6Q · 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid · in 2 records
- TCE · 3,3',3''-phosphanetriyltripropanoic acid · in 2 records
- BNG · nonyl beta-D-glucopyranoside · in 1 record
- SR5 · (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid · in 1 record
- SR9 · (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid · in 1 record
- SRW · 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol · in 1 record
Experiment against prediction
- 8FN0 chain A against the predicted model P20789: TM-score 0.99, RMSD 0.69 Å
- 8FMZ chain A against the predicted model P20789: TM-score 0.98, RMSD 0.83 Å
- 8FN1 chain A against the predicted model P20789: TM-score 0.98, RMSD 0.84 Å
- 7L0R chain C against the predicted model P20789: TM-score 0.97, RMSD 1.09 Å
- 7L0R chain C against the predicted model P20789: TM-score 0.97, RMSD 1.09 Å
- 7L0S chain C against the predicted model P20789: TM-score 0.97, RMSD 1.09 Å
- 7L0S chain C against the predicted model P20789: TM-score 0.97, RMSD 1.09 Å
- 7L0P chain C against the predicted model P20789: TM-score 0.96, RMSD 1.39 Å
- 7L0Q chain C against the predicted model P20789: TM-score 0.96, RMSD 1.39 Å
- 7L0P chain C against the predicted model P20789: TM-score 0.96, RMSD 1.39 Å
Elsewhere
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