MolNFT v1 · #271560 · protein
AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P20789)
P20789: “AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P20789)”. 5 pockets (best druggability 0.81). MolNFT v1 #271560 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P20789
- Type
- protein
- Length
- 424 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x422f92Ed16F3e38E0Df945A0deE92D80fCDFD0FB
- Molecule
- Neurotensin receptor type 1
- UniProt
- P20789
- Pockets
- 5 · best druggability 0.81
Structure
1 distinct chain · 68% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurotensin receptor type 1 | protein | 424 | 68% helix, 2% strand | P20789 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 406 | 0.81 | 0.89 | 41 | empty |
| 2 | 58 | 0.68 | 0.96 | 22 | empty |
| 3 | 74 | 0.64 | 0.92 | 16 | empty |
| 4 | 248 | 0.55 | 0.77 | 29 | empty |
| 5 | 63 | 0.33 | 0.77 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4XES · Structure of active-like neurotensin receptor · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 4XES · Structure of active-like neurotensin receptor · an experimental structure of the same protein · chain A against A, TM-score 0.72
- 7L0R · Structure of nts-NTSR1-gi complex in lipid nanodisc, noncanonical state, without ahd · an experimental structure of the same protein · chain A against C, TM-score 0.71
- 7L0R · Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, without AHD · an experimental structure of the same protein · chain A against C, TM-score 0.71
- 7L0S · Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, with AHD · an experimental structure of the same protein · chain A against C, TM-score 0.71
- 7L0S · Structure of nts-NTSR1-gi complex in lipid nanodisc, noncanonical state, with ahd · an experimental structure of the same protein · chain A against C, TM-score 0.71
- 4GRV · The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13) · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 4GRV · The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13) · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 7L0P · Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, without AHD · an experimental structure of the same protein · chain A against C, TM-score 0.71
- 7L0P · Structure of nts-NTSR1-gi complex in lipid nanodisc, canonical state, without ahd · an experimental structure of the same protein · chain A against C, TM-score 0.71
- 7L0Q · Structure of nts-NTSR1-gi complex in lipid nanodisc, canonical state, with ahd · an experimental structure of the same protein · chain A against C, TM-score 0.71
- 7L0Q · Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, with AHD · an experimental structure of the same protein · chain A against C, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20789
- Elsewhere: UniProt P20789 · AlphaFold DB P20789
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