MolNFT v1 · #180477 · protein
Structure of nts-NTSR1-gi complex in lipid nanodisc, noncanonical state, with ahd
7L0S · Neurotensin receptor type 1: “Structure of nts-NTSR1-gi complex in lipid nanodisc, noncanonical state, with ahd”. Electron microscopy, 11 pockets (best druggability 0.81). MolNFT v1 #180477 on GenesisL1: 3D structure, binding sites…
- PDB
- 7L0S
- Type
- protein
- Length
- 1,001 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurotensin receptor type 1; Neurotensin; Guanine nucleotide-binding protein G(I) subunit…
- UniProt
- P20789, P20068, P63096, P62873, P63211
- Pockets
- 11 · best druggability 0.81
Structure
electron microscopy · 5 distinct chains · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Neurotensin receptor type 1 | protein | 308 | 78% helix, 3% strand | P20789 |
| D | Neurotensin | protein | 6 | 0% helix, 0% strand | P20068 |
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 337 | 53% helix, 11% strand | P63096 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 311 | 0% helix, 48% strand | P62873 |
| G | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | protein | 39 | 38% helix, 0% strand | P63211 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 682 | 0.81 | 0.85 | 67 | empty |
| 2 | 753 | 0.78 | 0.82 | 67 | empty |
| 3 | 349 | 0.65 | 0.80 | 42 | empty |
| 4 | 214 | 0.63 | 0.82 | 28 | empty |
| 5 | 93 | 0.57 | 0.86 | 24 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1787 Ų buried · 16 hydrogen bonds · protein-protein
- B–G · 1407 Ų buried · 9 hydrogen bonds · protein-protein
- C–A · 1075 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 804 Ų buried · 11 hydrogen bonds · protein-protein
- C–B · 169 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7L0S · Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, with AHD · the same entry in another collection · chain G against G, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P20789 · AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P20789) · a predicted model of the same protein · chain C against A, TM-score 0.97
- P63211 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain G against A, TM-score 0.81
- P20068 · AlphaFold monomer V2.0 prediction for NEUROTENSIN/NEUROMEDIN N (P20068) · a predicted model of the same protein · chain D against A, TM-score 0.72
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20789
- Every structure of UniProt P20068
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P63211
- Elsewhere: RCSB PDB 7L0S · PDBe 7L0S · UniProt P20789 · UniProt P20068 · UniProt P63096 · UniProt P62873 · UniProt P63211
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