Crystal structure of T2R-ttl-(+)-6-br-JP18 complex

Structure

x-ray diffraction · 6 distinct chains.

Ligands and binding sites

• GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, C
• G9U · (6R)-6-[(6-bromanyl-1H-indol-3-yl)methyl]-6,7,8,9-tetrahydrobenzo[7]annulen-5-one · ligand · 2 copies · chains A, B, C, D
• GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, D
• MG · Magnesium ion · metal · 3 copies · chains B, C
• CA · Calcium ion · metal · 3 copies · chains A, B
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B
• GOL · Glycerol · additive · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7CPD · Crystal structure of T2R-TTL-(+)-6-Br-JP18 complex · the same entry in another collection · chain C against C, TM-score 1.00
• Q9H169 · AlphaFold monomer V2.0 prediction for stathmin-4 (Q9H169) · a predicted model of the same protein · chain E against A, TM-score 0.76

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P81947
• Every structure of UniProt Q6B856
• Every structure of UniProt Q9H169
• Every structure of UniProt E1BQ43
• Elsewhere: RCSB PDB 7CPD · PDBe 7CPD · UniProt P81947 · UniProt Q6B856 · UniProt Q9H169 · UniProt E1BQ43