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Structure of a minimal SF3B core in complex with spliceostatin a (form I)

Analyse Structure of a minimal SF3B core in complex with spliceostatin a (form I) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7B9C
Type
protein
Length
1,878 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
Q921M3, Q15393, Q9BWJ5, O75533, Q7RTV0
Ligands
SJT, ZN, SCN

Structure

x-ray diffraction · 4 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein870—Q921M3, Q15393
B—protein74—Q9BWJ5
C—protein842—O75533
D—protein92—Q7RTV0

Ligands and binding sites

  • SJT · spliceostatin A (form II) · ligand · chains C, D
  • ZN · Zinc ion · metal · 3 copies · chains D
  • SCN · Thiocyanate ion · ion · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7B9C · Structure of a minimal SF3B core in complex with spliceostatin A (form I) · the same entry in another collection · chain A against A, TM-score 1.00
  • Q15393 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q15393) · a predicted model of the same protein · chain A against A, TM-score 0.99
  • Q921M3 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q921M3) · a predicted model of the same protein · chain A against A, TM-score 0.99
  • Q7RTV0 · AlphaFold monomer V2.0 prediction for phd finger-like domain- containing protein 5A… · a predicted model of the same protein · chain D against A, TM-score 0.89
  • Q9BWJ5 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 5 (Q9BWJ5) · a predicted model of the same protein · chain B against A, TM-score 0.88
  • O75533 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 1 (O75533) · a predicted model of the same protein · chain C against A, TM-score 0.80

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