MolNFT v1 · #427053 · protein
AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q15393)
Q15393: “AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q15393)”. 12 pockets (best druggability 0.87). MolNFT v1 #427053 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q15393
- Type
- protein
- Length
- 1,217 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6F9f9CD1Df14e89bB8FDF55C2ABa04A409c977B4
- Molecule
- Splicing factor 3B subunit 3
- UniProt
- Q15393
- Pockets
- 12 · best druggability 0.87
Structure
1 distinct chain · 9% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor 3B subunit 3 | protein | 1217 | 9% helix, 48% strand | Q15393 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 997 | 0.87 | 0.88 | 109 | empty |
| 2 | 901 | 0.82 | 0.84 | 81 | empty |
| 3 | 929 | 0.81 | 0.83 | 57 | empty |
| 4 | 286 | 0.75 | 0.88 | 44 | empty |
| 5 | 970 | 0.74 | 0.77 | 57 | empty |
Compared structures
- 7Q3L · Human 17S U2 snrnp 5' domain · an experimental structure of the same protein · chain A against C, TM-score 0.97
- 7Q3L · Human 17S U2 snRNP 5' domain · an experimental structure of the same protein · chain A against C, TM-score 0.97
- 7DVQ · Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) · an experimental structure of the same protein · chain A against 3, TM-score 0.96
- 7DVQ · Cryo-EM structure of the activated human minor spliceosome (minor bact complex) · an experimental structure of the same protein · chain A against 3, TM-score 0.96
- 8Y7E · Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U12… · an experimental structure of the same protein · chain A against 3, TM-score 0.96
- 8I0P · The cryo-EM structure of human pre-Bact complex · an experimental structure of the same protein · chain A against 3, TM-score 0.96
- 7ABG · Human pre-Bact-1 spliceosome · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 7ABI · Human pre-bact-2 spliceosome · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 7ABI · Human pre-Bact-2 spliceosome · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 7ABH · Human pre-bact-2 spliceosome (SF3B/U2 snrnp portion) · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 7ABH · Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion) · an experimental structure of the same protein · chain A against E, TM-score 0.96
- 7EVO · The cryo-EM structure of the human 17S U2 snrnp · an experimental structure of the same protein · chain A against 3, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15393
- Elsewhere: UniProt Q15393 · AlphaFold DB Q15393
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