MolNFT v1 · #427054 · protein
AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q921M3)
Q921M3: “AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 3 (Q921M3)”. 13 pockets (best druggability 0.85). MolNFT v1 #427054 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q921M3
- Type
- protein
- Length
- 1,217 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x0D671490EE06E75975e90D7F99F73B20BE618744
- Molecule
- Splicing factor 3B subunit 3
- UniProt
- Q921M3
- Pockets
- 13 · best druggability 0.85
Structure
1 distinct chain · 9% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor 3B subunit 3 | protein | 1217 | 9% helix, 48% strand | Q921M3 |
Pockets
13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1068 | 0.85 | 0.86 | 111 | empty |
| 2 | 994 | 0.80 | 0.81 | 60 | empty |
| 3 | 1159 | 0.80 | 0.81 | 84 | empty |
| 4 | 888 | 0.73 | 0.77 | 54 | empty |
| 5 | 355 | 0.73 | 0.85 | 50 | empty |
Compared structures
- 7B9C · Structure of a minimal SF3B core in complex with spliceostatin a (form I) · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 7B9C · Structure of a minimal SF3B core in complex with spliceostatin A (form I) · an experimental structure of the same protein · chain A against A, TM-score 0.71
- 7OPI · Structure of a minimal SF3B core in complex with the inactive modulator spliceostatin E… · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 7OPI · Structure of a minimal SF3B core in complex with the inactive modulator spliceostatin E… · an experimental structure of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q921M3
- Elsewhere: UniProt Q921M3 · AlphaFold DB Q921M3
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