Research workbench
Yeast CTF19 complex
Analyse Yeast CTF19 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NUW
- Type
- protein
- Length
- 2,360 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inner kinetochore subunit IML3; Inner kinetochore subunit MCM21; Inner kinetochore…
- UniProt
- P38265, Q06675, Q02732, P38907, P53298, Q12493, P38313, Q12748, Q06162
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 13 distinct chains · 59% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Inner kinetochore subunit IML3 | protein | 244 | 27% helix, 20% strand | P38265 |
| C | Inner kinetochore subunit MCM21 | protein | 194 | 38% helix, 17% strand | Q06675 |
| D | Inner kinetochore subunit CTF19 | protein | 196 | 35% helix, 6% strand | Q02732 |
| E | Inner kinetochore subunit CHL4 | protein | 369 | 33% helix, 12% strand | P38907 |
| F | Inner kinetochore subunit OKP1 | protein | 190 | 77% helix, 0% strand | P53298 |
| G | Inner kinetochore subunit NKP1 | protein | 176 | 73% helix, 0% strand | Q12493 |
| I | Inner kinetochore subunit AME1 | protein | 168 | 88% helix, 0% strand | P38313 |
| H | Inner kinetochore subunit CTF3,INNER kinetochore subunit CTF3 | protein | 302 | 75% helix, 0% strand | Q12748 |
| J | Inner kinetochore subunit NKP2 | protein | 147 | 78% helix, 0% strand | Q06162 |
| Y | Inner kinetochore subunit CTF3,INNER kinetochore subunit CTF3 | protein | 150 | 71% helix, 0% strand | Q12748 |
| X | Inner kinetochore subunit MCM22 | protein | 126 | 90% helix, 0% strand | — |
| M | Inner kinetochore subunit MCM16 | protein | 75 | 89% helix, 0% strand | — |
| U | Unknown (unassigned) | protein | 23 | 91% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 809 | 0.85 | 0.88 | 76 | empty |
| 2 | 904 | 0.84 | 0.85 | 109 | empty |
| 3 | 342 | 0.82 | 0.91 | 59 | empty |
| 4 | 323 | 0.78 | 0.89 | 47 | empty |
| 5 | 849 | 0.76 | 0.80 | 86 | empty |
Interfaces
28 interfaces between chains.
- C–D · 2019 Ų buried · 9 hydrogen bonds · protein-protein
- F–I · 1943 Ų buried · 7 hydrogen bonds · protein-protein
- G–J · 1942 Ų buried · 9 hydrogen bonds · protein-protein
- C–E · 1573 Ų buried · 19 hydrogen bonds · protein-protein
- B–E · 1496 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 6NUW · Yeast Ctf19 complex · the same entry in another collection · chain U against U, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38265
- Every structure of UniProt Q06675
- Every structure of UniProt Q02732
- Every structure of UniProt P38907
- Every structure of UniProt P53298
- Every structure of UniProt Q12493
- Every structure of UniProt P38313
- Every structure of UniProt Q12748
- Every structure of UniProt Q06162
- Elsewhere: RCSB PDB 6NUW · PDBe 6NUW · UniProt P38265 · UniProt Q06675 · UniProt Q02732 · UniProt P38907 · UniProt P53298 · UniProt Q12493 · UniProt P38313 · UniProt Q12748 · UniProt Q06162
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.