UniProt Q12493
Inner kinetochore subunit NKP1 (Q12493)
Inner kinetochore subunit NKP1 (UniProt Q12493): 11 experimental structures and 1 predicted model on GenesisL1, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12493
- Protein
- Inner kinetochore subunit NKP1
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 42 · 6 records with a druggable one
Structures
12 records of Q12493 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NUW | Yeast CTF19 complex | electron microscopy | G | — | — |
| 6QLD | Structure of inner kinetochore CCAN-Cenp-A complex | electron microscopy | Y | — | — |
| 6QLD | Structure of inner kinetochore ccan-cenp-a complex | electron microscopy | Y | — | — |
| 6QLE | Structure of inner kinetochore CCAN complex | electron microscopy | Y | — | 6 (best 0.83) |
| 6QLE | Structure of inner kinetochore ccan complex | electron microscopy | Y | — | — |
| 6QLF | Structure of inner kinetochore CCAN complex with mask1 | electron microscopy | Y | — | 9 (best 0.83) |
| 6QLF | Structure of inner kinetochore ccan complex with MASK1 | electron microscopy | Y | — | — |
| 8OVW | Cryo-EM structure of CBF1-CCAN bound topologically to centromeric DNA | electron microscopy | Y | — | 8 (best 0.80) |
| 8OVX | Cryo-EM structure of yeast CENP-OPQU+ bound to the CENP-A N-terminus | electron microscopy | Y | — | 8 (best 0.84) |
| 8OW0 | Cryo-EM structure of CBF1-CCAN bound topologically to a centromeric CENP-A nucleosome | electron microscopy | Y | — | 4 (best 0.87) |
| 8OW1 | Cryo-EM structure of the yeast Inner kinetochore bound to a CENP-A nucleosome. | electron microscopy | Y, YY | — | 6 (best 0.85) |
| Q12493 | AlphaFold monomer V2.0 prediction for inner kinetochore subunit NKP1 (Q12493) | predicted | A | — | 1 (best 0.35) |
Experiment against prediction
- 8OVX chain Y against the predicted model Q12493: TM-score 0.48, RMSD 2.72 Å
- 8OVW chain Y against the predicted model Q12493: TM-score 0.46, RMSD 3.05 Å
- 6QLD chain Y against the predicted model Q12493: TM-score 0.45, RMSD 3.07 Å
- 6QLD chain Y against the predicted model Q12493: TM-score 0.45, RMSD 3.07 Å
- 6QLE chain Y against the predicted model Q12493: TM-score 0.45, RMSD 3.02 Å
- 6QLE chain Y against the predicted model Q12493: TM-score 0.45, RMSD 3.02 Å
- 6QLF chain Y against the predicted model Q12493: TM-score 0.45, RMSD 3.22 Å
- 6QLF chain Y against the predicted model Q12493: TM-score 0.45, RMSD 3.22 Å
- 8OW0 chain Y against the predicted model Q12493: TM-score 0.43, RMSD 3.12 Å
- 8OW1 chain Y against the predicted model Q12493: TM-score 0.43, RMSD 3.26 Å
Elsewhere
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