Research workbench
EIF2(AP) - EIF2B complex
Analyse EIF2(AP) - EIF2B complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6K72
- Type
- protein
- Length
- 4,264 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor eif-2B subunit alpha; Translation initiation factor eif-2B…
- UniProt
- Q14232, P49770, Q9NR50, Q9UI10, Q13144, P05198, P20042, P41091
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 11 distinct chains · 27% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor eif-2B subunit alpha | protein | 285 | 42% helix, 10% strand | Q14232 |
| B | Translation initiation factor eif-2B subunit alpha | protein | 284 | 39% helix, 12% strand | Q14232 |
| C, D | Translation initiation factor eif-2B subunit beta | protein | 318 | 44% helix, 12% strand | P49770 |
| E | Translation initiation factor eif-2B subunit gamma | protein | 333 | 14% helix, 13% strand | Q9NR50 |
| F | Translation initiation factor eif-2B subunit gamma | protein | 329 | 14% helix, 16% strand | Q9NR50 |
| G, H | Translation initiation factor eif-2B subunit delta | protein | 357 | 41% helix, 13% strand | Q9UI10 |
| I, J | Translation initiation factor eif-2B subunit epsilon | protein | 421 | 19% helix, 20% strand | Q13144 |
| K | Eukaryotic translation initiation factor 2 subunit 1 | protein | 239 | 36% helix, 12% strand | P05198 |
| L | Eukaryotic translation initiation factor 2 subunit 1 | protein | 165 | 15% helix, 6% strand | P05198 |
| M | Eukaryotic translation initiation factor 2 subunit 2 | protein | 16 | 69% helix, 0% strand | P20042 |
| P | Eukaryotic translation initiation factor 2 subunit 3 | protein | 421 | 7% helix, 17% strand | P41091 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1146 | 0.87 | 0.88 | 129 | empty |
| 2 | 1000 | 0.83 | 0.84 | 102 | empty |
| 3 | 1073 | 0.83 | 0.84 | 111 | empty |
| 4 | 1037 | 0.81 | 0.82 | 121 | empty |
| 5 | 816 | 0.80 | 0.84 | 78 | empty |
Interfaces
30 interfaces between chains.
- C–G · 2267 Ų buried · 20 hydrogen bonds · protein-protein
- D–H · 2233 Ų buried · 13 hydrogen bonds · protein-protein
- C–I · 1289 Ų buried · 16 hydrogen bonds · protein-protein
- D–J · 1282 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1229 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6K72 · eIF2(aP) - eIF2B complex · the same entry in another collection · chain M against M, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14232
- Every structure of UniProt P49770
- Every structure of UniProt Q9NR50
- Every structure of UniProt Q9UI10
- Every structure of UniProt Q13144
- Every structure of UniProt P05198
- Every structure of UniProt P20042
- Every structure of UniProt P41091
- Elsewhere: RCSB PDB 6K72 · PDBe 6K72 · UniProt Q14232 · UniProt P49770 · UniProt Q9NR50 · UniProt Q9UI10 · UniProt Q13144 · UniProt P05198 · UniProt P20042 · UniProt P41091
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.