UniProt P49770
Translation initiation factor eIF-2B subunit beta (P49770)
Translation initiation factor eIF-2B subunit beta (UniProt P49770): 42 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 199 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P49770
- Protein
- Translation initiation factor eIF-2B subunit beta
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 199 · 20 records with a druggable one
Structures
43 records of P49770 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens | electron microscopy | C, D | C7B | — |
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens | electron microscopy | C, D | C7B | — |
| 6EZO | Eukaryotic initiation factor EIF2B in complex with ISRIB | electron microscopy | C, D | C7B | 8 (best 0.88) |
| 6EZO | Eukaryotic initiation factor EIF2B in complex with isrib | electron microscopy | C, D | C7B | — |
| 6K71 | eIF2 - eIF2B complex | electron microscopy | C, D | — | — |
| 6K71 | EIF2 - EIF2B complex | electron microscopy | C, D | — | — |
| 6K72 | eIF2(aP) - eIF2B complex | electron microscopy | C, D | — | 7 (best 0.87) |
| 6K72 | EIF2(AP) - EIF2B complex | electron microscopy | C, D | — | — |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | C, D | C7B | 10 (best 0.84) |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | C, D | C7B | — |
| 6O85 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | C, D | C7B | 10 (best 0.87) |
| 6O85 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | C, D | C7B | — |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | C, D | — | 11 (best 0.86) |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | C, D | — | — |
| 7D43 | eIF2B-eIF2(aP), aPg complex | electron microscopy | C, D | — | 8 (best 0.87) |
| 7D43 | EIF2B-EIF2(AP), apg complex | electron microscopy | C, D | — | — |
| 7D44 | eIF2B-eIF2(aP), aP2 complex | electron microscopy | C, D | — | 7 (best 0.86) |
| 7D44 | EIF2B-EIF2(AP), AP2 complex | electron microscopy | C, D | — | — |
| 7D45 | eIF2B-eIF2(aP), aP1 complex | electron microscopy | C, D | — | 10 (best 0.86) |
| 7D45 | EIF2B-EIF2(AP), AP1 complex | electron microscopy | C, D | — | — |
| 7D46 | eIF2B apo | electron microscopy | C, D | — | 9 (best 0.87) |
| 7D46 | EIF2B APO | electron microscopy | C, D | — | — |
| 7F64 | eIF2B-SFSV NSs | electron microscopy | C, D | — | 10 (best 0.86) |
| 7F64 | EIF2B-sfsv nss | electron microscopy | C, D | — | — |
| 7F66 | eIF2B-SFSV NSs-1-eIF2 | electron microscopy | C, D | — | 11 (best 0.86) |
| 7F66 | EIF2B-sfsv nss-1-EIF2 | electron microscopy | C, D | — | — |
| 7F67 | eIF2B-SFSV NSs-2-eIF2 | electron microscopy | C, D | — | 8 (best 0.86) |
| 7F67 | EIF2B-sfsv nss-2-EIF2 | electron microscopy | C, D | — | — |
| 7KMF | Sugar phosphate activation of the stress sensor eIF2B | electron microscopy | C, D | — | 13 (best 0.85) |
| 7KMF | Sugar phosphate activation of the stress sensor EIF2B | electron microscopy | C, D | — | — |
| 7L70 | The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form | electron microscopy | C, D | — | 15 (best 0.84) |
| 7L70 | The eukaryotic translation initiation factor 2B from homo sapiens in its apo form | electron microscopy | C, D | — | — |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens… | electron microscopy | C, D | C7B | 13 (best 0.84) |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens… | electron microscopy | C, D | C7B | — |
| 7RLO | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral… | electron microscopy | C, D | — | 10 (best 0.86) |
| 7RLO | Structure of the human eukaryotic translation initiation factor 2B (EIF2B) in complex with a viral… | electron microscopy | C, D | — | — |
| 7TRJ | The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta… | electron microscopy | D, C | — | 12 (best 0.86) |
| 7TRJ | The eukaryotic translation initiation factor 2B from homo sapiens with a H160D mutation in the beta… | electron microscopy | D, C | — | — |
| 7VLK | eIF2B-SFSV NSs C2-imposed | electron microscopy | C, D | — | 11 (best 0.85) |
| 7VLK | EIF2B-sfsv nss C2-imposed | electron microscopy | C, D | — | — |
| 8TQO | Eukaryotic translation initiation factor 2B tetramer | electron microscopy | D | — | 5 (best 0.80) |
| 8TQZ | Eukaryotic translation initiation factor 2B with a mutation (L516A) in the delta subunit | electron microscopy | D, C | — | 11 (best 0.80) |
| P49770 | AlphaFold monomer V2.0 prediction for translation initiation factor eif-2B subunit beta (P49770) | predicted | A | — | — |
Ligands
- C7B · 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy) ethanoylamino]cyclohexyl]ethanamide · in 10 records
Experiment against prediction
- 6O9Z chain C against the predicted model P49770: TM-score 0.98, RMSD 0.92 Å
- 6O9Z chain C against the predicted model P49770: TM-score 0.98, RMSD 0.92 Å
- 6O85 chain C against the predicted model P49770: TM-score 0.98, RMSD 0.94 Å
- 6O85 chain C against the predicted model P49770: TM-score 0.98, RMSD 0.94 Å
- 7KMF chain D against the predicted model P49770: TM-score 0.98, RMSD 0.98 Å
- 7KMF chain D against the predicted model P49770: TM-score 0.98, RMSD 0.98 Å
- 6O81 chain C against the predicted model P49770: TM-score 0.98, RMSD 0.98 Å
- 6O81 chain C against the predicted model P49770: TM-score 0.98, RMSD 0.98 Å
- 7L7G chain C against the predicted model P49770: TM-score 0.98, RMSD 1.04 Å
- 7L7G chain C against the predicted model P49770: TM-score 0.98, RMSD 1.04 Å
Elsewhere
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