UniProt Q13144
Translation initiation factor eIF-2B subunit epsilon (Q13144)
Translation initiation factor eIF-2B subunit epsilon (UniProt Q13144): 38 experimental structures and 1 predicted model on GenesisL1, 121 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13144
- Protein
- Translation initiation factor eIF-2B subunit epsilon
- Experimental structures
- 38
- Predicted models
- 1
- Pockets
- 121 · 14 records with a druggable one
Structures
39 records of Q13144 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JUI | Crystal Structure of the C-terminal Domain of Human Translation Initiation Factor eIF2B epsilon… | x-ray diffraction | A | — | — |
| 3JUI | Crystal structure of the C-terminal domain of human translation initiation factor EIF2B epsilon… | x-ray diffraction | A | — | — |
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens | electron microscopy | B, A | — | — |
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens | electron microscopy | B, A | — | — |
| 6EZO | Eukaryotic initiation factor EIF2B in complex with ISRIB | electron microscopy | I, J | — | 9 (best 0.87) |
| 6EZO | Eukaryotic initiation factor EIF2B in complex with isrib | electron microscopy | I, J | — | — |
| 6K71 | eIF2 - eIF2B complex | electron microscopy | I, J | — | — |
| 6K71 | EIF2 - EIF2B complex | electron microscopy | I, J | — | — |
| 6K72 | EIF2(AP) - EIF2B complex | electron microscopy | I, J | — | — |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | A, B | — | 9 (best 0.87) |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | A, B | — | — |
| 6O85 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | A, B | — | — |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | A, B | — | 7 (best 0.86) |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | A, B | — | — |
| 7D43 | eIF2B-eIF2(aP), aPg complex | electron microscopy | I, J | — | 6 (best 0.87) |
| 7D43 | EIF2B-EIF2(AP), apg complex | electron microscopy | I, J | — | — |
| 7D44 | eIF2B-eIF2(aP), aP2 complex | electron microscopy | I, J | — | 5 (best 0.79) |
| 7D44 | EIF2B-EIF2(AP), AP2 complex | electron microscopy | I, J | — | — |
| 7D45 | eIF2B-eIF2(aP), aP1 complex | electron microscopy | I, J | — | 8 (best 0.86) |
| 7D45 | EIF2B-EIF2(AP), AP1 complex | electron microscopy | I, J | — | — |
| 7D46 | EIF2B APO | electron microscopy | I, J | — | — |
| 7F64 | eIF2B-SFSV NSs | electron microscopy | I, J | — | 11 (best 0.86) |
| 7F64 | EIF2B-sfsv nss | electron microscopy | I, J | — | — |
| 7F66 | eIF2B-SFSV NSs-1-eIF2 | electron microscopy | I, J | — | 9 (best 0.86) |
| 7F66 | EIF2B-sfsv nss-1-EIF2 | electron microscopy | I, J | — | — |
| 7F67 | EIF2B-sfsv nss-2-EIF2 | electron microscopy | I, J | — | — |
| 7KMF | Sugar phosphate activation of the stress sensor EIF2B | electron microscopy | B, I | — | — |
| 7L70 | The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form | electron microscopy | A, B | — | 10 (best 0.84) |
| 7L70 | The eukaryotic translation initiation factor 2B from homo sapiens in its apo form | electron microscopy | A, B | — | — |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens… | electron microscopy | B, A | — | 6 (best 0.77) |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens… | electron microscopy | B, A | — | — |
| 7RLO | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral… | electron microscopy | A, B | — | 11 (best 0.86) |
| 7RLO | Structure of the human eukaryotic translation initiation factor 2B (EIF2B) in complex with a viral… | electron microscopy | A, B | — | — |
| 7TRJ | The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta… | electron microscopy | A, B | — | 11 (best 0.86) |
| 7TRJ | The eukaryotic translation initiation factor 2B from homo sapiens with a H160D mutation in the beta… | electron microscopy | A, B | — | — |
| 7VLK | eIF2B-SFSV NSs C2-imposed | electron microscopy | I, J | — | 11 (best 0.85) |
| 7VLK | EIF2B-sfsv nss C2-imposed | electron microscopy | I, J | — | — |
| 8TQO | Eukaryotic translation initiation factor 2B tetramer | electron microscopy | A | — | 8 (best 0.80) |
| Q13144 | AlphaFold monomer V2.0 prediction for translation initiation factor eif-2B subunit epsilon (Q13144) | predicted | A | — | — |
Experiment against prediction
- 7TRJ chain A against the predicted model Q13144: TM-score 0.99, RMSD 1.08 Å
- 7TRJ chain B against the predicted model Q13144: TM-score 0.99, RMSD 1.08 Å
- 7TRJ chain A against the predicted model Q13144: TM-score 0.99, RMSD 1.08 Å
- 7TRJ chain B against the predicted model Q13144: TM-score 0.99, RMSD 1.08 Å
- 7RLO chain A against the predicted model Q13144: TM-score 0.99, RMSD 1.08 Å
- 7RLO chain A against the predicted model Q13144: TM-score 0.99, RMSD 1.08 Å
- 7L70 chain A against the predicted model Q13144: TM-score 0.98, RMSD 1.10 Å
- 7L70 chain A against the predicted model Q13144: TM-score 0.98, RMSD 1.10 Å
- 7L70 chain B against the predicted model Q13144: TM-score 0.98, RMSD 1.10 Å
- 7L70 chain B against the predicted model Q13144: TM-score 0.98, RMSD 1.10 Å
Elsewhere
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