UniProt Q9UI10
Translation initiation factor eIF-2B subunit delta (Q9UI10)
Translation initiation factor eIF-2B subunit delta (UniProt Q9UI10): 31 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 92 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9UI10
- Protein
- Translation initiation factor eIF-2B subunit delta
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 92 · 9 records with a druggable one
Structures
32 records of Q9UI10 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens | electron microscopy | F, E | C7B | — |
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens | electron microscopy | F, E | C7B | — |
| 6EZO | Eukaryotic initiation factor EIF2B in complex with isrib | electron microscopy | G, H | C7B | — |
| 6K71 | eIF2 - eIF2B complex | electron microscopy | G, H | — | — |
| 6K71 | EIF2 - EIF2B complex | electron microscopy | G, H | — | — |
| 6K72 | EIF2(AP) - EIF2B complex | electron microscopy | G, H | — | — |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | E, F | C7B | — |
| 6O85 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | E, F | C7B | — |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | E, F | — | 11 (best 0.86) |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | E, F | — | — |
| 7D43 | eIF2B-eIF2(aP), aPg complex | electron microscopy | G, H | — | 9 (best 0.87) |
| 7D43 | EIF2B-EIF2(AP), apg complex | electron microscopy | G, H | — | — |
| 7D44 | EIF2B-EIF2(AP), AP2 complex | electron microscopy | G, H | — | — |
| 7D45 | eIF2B-eIF2(aP), aP1 complex | electron microscopy | G, H | — | 9 (best 0.86) |
| 7D45 | EIF2B-EIF2(AP), AP1 complex | electron microscopy | G, H | — | — |
| 7D46 | EIF2B APO | electron microscopy | G, H | — | — |
| 7F64 | EIF2B-sfsv nss | electron microscopy | G, H | — | — |
| 7F66 | eIF2B-SFSV NSs-1-eIF2 | electron microscopy | G, H | — | 9 (best 0.86) |
| 7F66 | EIF2B-sfsv nss-1-EIF2 | electron microscopy | G, H | — | — |
| 7F67 | EIF2B-sfsv nss-2-EIF2 | electron microscopy | G, H | — | — |
| 7KMF | Sugar phosphate activation of the stress sensor EIF2B | electron microscopy | F, E | — | — |
| 7L70 | The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form | electron microscopy | E, F | — | 13 (best 0.84) |
| 7L70 | The eukaryotic translation initiation factor 2B from homo sapiens in its apo form | electron microscopy | E, F | — | — |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens… | electron microscopy | F, E | C7B | 11 (best 0.84) |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens… | electron microscopy | F, E | C7B | — |
| 7RLO | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral… | electron microscopy | E, F | — | 12 (best 0.86) |
| 7RLO | Structure of the human eukaryotic translation initiation factor 2B (EIF2B) in complex with a viral… | electron microscopy | E, F | — | — |
| 7TRJ | The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta… | electron microscopy | E, F | — | 11 (best 0.86) |
| 7TRJ | The eukaryotic translation initiation factor 2B from homo sapiens with a H160D mutation in the beta… | electron microscopy | E, F | — | — |
| 7VLK | EIF2B-sfsv nss C2-imposed | electron microscopy | G, H | — | — |
| 8TQO | Eukaryotic translation initiation factor 2B tetramer | electron microscopy | E | — | 7 (best 0.80) |
| Q9UI10 | AlphaFold monomer V2.0 prediction for translation initiation factor eif-2B subunit delta (Q9UI10) | predicted | A | — | — |
Ligands
- C7B · 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy) ethanoylamino]cyclohexyl]ethanamide · in 7 records
Experiment against prediction
- 7KMF chain F against the predicted model Q9UI10: TM-score 0.98, RMSD 0.85 Å
- 7VLK chain H against the predicted model Q9UI10: TM-score 0.98, RMSD 0.97 Å
- 7VLK chain G against the predicted model Q9UI10: TM-score 0.98, RMSD 0.98 Å
- 7F66 chain H against the predicted model Q9UI10: TM-score 0.98, RMSD 0.99 Å
- 7F66 chain H against the predicted model Q9UI10: TM-score 0.98, RMSD 0.99 Å
- 7KMF chain E against the predicted model Q9UI10: TM-score 0.98, RMSD 0.93 Å
- 7RLO chain F against the predicted model Q9UI10: TM-score 0.98, RMSD 0.99 Å
- 7RLO chain F against the predicted model Q9UI10: TM-score 0.98, RMSD 0.99 Å
- 7F64 chain G against the predicted model Q9UI10: TM-score 0.98, RMSD 0.99 Å
- 7F64 chain H against the predicted model Q9UI10: TM-score 0.98, RMSD 0.99 Å
Elsewhere
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