UniProt Q14232
Translation initiation factor eIF-2B subunit alpha (Q14232)
Translation initiation factor eIF-2B subunit alpha (UniProt Q14232): 31 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q14232
- Protein
- Translation initiation factor eIF-2B subunit alpha
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 57 · 6 records with a druggable one
Structures
32 records of Q14232 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ECS | Crystal structure of human eIF2B alpha | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3ECS | Crystal structure of human EIF2B alpha | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens | electron microscopy | H, G | — | — |
| 6CAJ | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens | electron microscopy | H, G | — | — |
| 6EZO | Eukaryotic initiation factor EIF2B in complex with isrib | electron microscopy | A, B | — | — |
| 6K71 | eIF2 - eIF2B complex | electron microscopy | A, B | — | — |
| 6K71 | EIF2 - EIF2B complex | electron microscopy | A, B | — | — |
| 6K72 | EIF2(AP) - EIF2B complex | electron microscopy | A, B | — | — |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | G, H | — | — |
| 6O85 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | G, H | — | — |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | G, H | — | — |
| 7D43 | eIF2B-eIF2(aP), aPg complex | electron microscopy | A, B | — | 8 (best 0.87) |
| 7D43 | EIF2B-EIF2(AP), apg complex | electron microscopy | A, B | — | — |
| 7D44 | EIF2B-EIF2(AP), AP2 complex | electron microscopy | A, B | — | — |
| 7D45 | eIF2B-eIF2(aP), aP1 complex | electron microscopy | A, B | — | 7 (best 0.86) |
| 7D45 | EIF2B-EIF2(AP), AP1 complex | electron microscopy | A, B | — | — |
| 7D46 | EIF2B APO | electron microscopy | A, B | — | — |
| 7F64 | EIF2B-sfsv nss | electron microscopy | A, B | — | — |
| 7F66 | EIF2B-sfsv nss-1-EIF2 | electron microscopy | A, B | — | — |
| 7F67 | EIF2B-sfsv nss-2-EIF2 | electron microscopy | A, B | — | — |
| 7KMA | Crystal structure of eif2Balpha with a ligand. | x-ray diffraction | A, B, C, D, E, F, G, H | M6P | 20 (best 0.69) |
| 7KMA | Crystal structure of EIF2BALPHA with a ligand. | x-ray diffraction | A, B, C, D, E, F, G, H | M6P | — |
| 7KMF | Sugar phosphate activation of the stress sensor EIF2B | electron microscopy | H, G | F6P | — |
| 7L70 | The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form | electron microscopy | G, H | — | 7 (best 0.84) |
| 7L70 | The eukaryotic translation initiation factor 2B from homo sapiens in its apo form | electron microscopy | G, H | — | — |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens… | electron microscopy | H, G | — | 8 (best 0.84) |
| 7L7G | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from homo sapiens… | electron microscopy | H, G | — | — |
| 7RLO | Structure of the human eukaryotic translation initiation factor 2B (EIF2B) in complex with a viral… | electron microscopy | G, H | — | — |
| 7TRJ | The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta… | electron microscopy | G, H | — | 7 (best 0.86) |
| 7TRJ | The eukaryotic translation initiation factor 2B from homo sapiens with a H160D mutation in the beta… | electron microscopy | G, H | — | — |
| 7VLK | EIF2B-sfsv nss C2-imposed | electron microscopy | A, B | — | — |
| Q14232 | AlphaFold monomer V2.0 prediction for translation initiation factor eif-2B subunit alpha (Q14232) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7KMA chain G against the predicted model Q14232: TM-score 0.98, RMSD 0.79 Å
- 7KMA chain G against the predicted model Q14232: TM-score 0.98, RMSD 0.79 Å
- 7KMA chain E against the predicted model Q14232: TM-score 0.98, RMSD 0.87 Å
- 7KMA chain E against the predicted model Q14232: TM-score 0.98, RMSD 0.87 Å
- 6O9Z chain H against the predicted model Q14232: TM-score 0.98, RMSD 0.79 Å
- 6O9Z chain G against the predicted model Q14232: TM-score 0.98, RMSD 0.79 Å
- 7KMA chain H against the predicted model Q14232: TM-score 0.98, RMSD 0.79 Å
- 7KMA chain H against the predicted model Q14232: TM-score 0.98, RMSD 0.79 Å
- 7KMF chain G against the predicted model Q14232: TM-score 0.98, RMSD 0.89 Å
- 7KMF chain H against the predicted model Q14232: TM-score 0.98, RMSD 0.89 Å
Elsewhere
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