UniProt P05198
Eukaryotic translation initiation factor 2 subunit 1 (P05198)
Eukaryotic translation initiation factor 2 subunit 1 (UniProt P05198): 40 experimental structures on GenesisL1, 1 ligand bound, 51 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P05198
- Protein
- Eukaryotic translation initiation factor 2 subunit 1
- Experimental structures
- 40
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 51 · 13 records with a druggable one
Structures
40 records of P05198 in the MolNFT archive: 40 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KL9 | Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha | x-ray diffraction | A | — | — |
| 1KL9 | Crystal structure of the N-terminal segment of human eukaryotic initiation factor 2ALPHA | x-ray diffraction | A | — | — |
| 1Q8K | Solution structure of alpha subunit of human eIF2 | solution nmr | A | — | — |
| 1Q8K | Solution structure of alpha subunit of human EIF2 | solution nmr | A | — | — |
| 6K71 | eIF2 - eIF2B complex | electron microscopy | K | — | — |
| 6K71 | EIF2 - EIF2B complex | electron microscopy | K | — | — |
| 6K72 | EIF2(AP) - EIF2B complex | electron microscopy | K, L | — | — |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | L, M | — | 6 (best 0.87) |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | L, M | — | — |
| 6O85 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | L | — | — |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | L, M | — | 7 (best 0.76) |
| 6O9Z | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | L, M | — | — |
| 6YBV | Structure of a human 48S translational initiation complex - eIF2-TC | electron microscopy | r | — | 6 (best 0.78) |
| 6YBV | Structure of a human 48S translational initiation complex - EIF2-tc | electron microscopy | r | — | — |
| 6ZP4 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 | electron microscopy | O | — | 1 (best 0.83) |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | O | — | — |
| 7D43 | eIF2B-eIF2(aP), aPg complex | electron microscopy | K, L | — | 6 (best 0.79) |
| 7D43 | EIF2B-EIF2(AP), apg complex | electron microscopy | K, L | — | — |
| 7D44 | eIF2B-eIF2(aP), aP2 complex | electron microscopy | K, L | — | 5 (best 0.78) |
| 7D44 | EIF2B-EIF2(AP), AP2 complex | electron microscopy | K, L | — | — |
| 7D45 | eIF2B-eIF2(aP), aP1 complex | electron microscopy | K | — | 2 (best 0.78) |
| 7D45 | EIF2B-EIF2(AP), AP1 complex | electron microscopy | K | — | — |
| 7F66 | eIF2B-SFSV NSs-1-eIF2 | electron microscopy | N | — | 3 (best 0.81) |
| 7F66 | EIF2B-sfsv nss-1-EIF2 | electron microscopy | N | — | — |
| 7F67 | eIF2B-SFSV NSs-2-eIF2 | electron microscopy | N, Q | — | 6 (best 0.82) |
| 7F67 | EIF2B-sfsv nss-2-EIF2 | electron microscopy | N, Q | — | — |
| 7NZM | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped… | electron microscopy | E | MN | 4 (best 0.67) |
| 7NZM | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated EIF2ALPHA with trapped… | electron microscopy | E | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | r | — | — |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | r | — | — |
| 7SYR | Structure of the wt ires EIF2-containing 48S initiation complex, closed conformation. structure… | electron microscopy | j | — | — |
| 7SYS | Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation.… | electron microscopy | j | — | — |
| 7SYS | Structure of the delta dii ires EIF2-containing 48S initiation complex, closed conformation.… | electron microscopy | j | — | — |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | D | — | 1 (best 0.86) |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | r | — | — |
| 8PJ2 | Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced… | electron microscopy | r | — | 1 (best 0.84) |
| 8PJ3 | Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B… | electron microscopy | r | — | 1 (best 0.89) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | Ir | — | — |
| 8QZZ | Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452 | x-ray diffraction | B | — | 2 (best 0.46) |
| P05198 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2 subunit 1 (P05198) | — | — | — |
Ligands
- MN · Manganese (II) ion · in 1 record
Elsewhere
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