UniProt P41091
Eukaryotic translation initiation factor 2 subunit 3 (P41091)
Eukaryotic translation initiation factor 2 subunit 3 (UniProt P41091), EC 3.6.5.3: 21 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 34 pockets. Binding sites, druggability and experiment against…
- UniProt
- P41091
- Protein
- Eukaryotic translation initiation factor 2 subunit 3
- EC
- 3.6.5.3
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 34 · 5 records with a druggable one
Structures
22 records of P41091 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6K71 | eIF2 - eIF2B complex | electron microscopy | P | — | — |
| 6K71 | EIF2 - EIF2B complex | electron microscopy | P | — | — |
| 6K72 | EIF2(AP) - EIF2B complex | electron microscopy | P | — | — |
| 6O81 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation… | electron microscopy | S, T | — | — |
| 6O85 | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic… | electron microscopy | S | — | — |
| 6YBV | Structure of a human 48S translational initiation complex - eIF2-TC | electron microscopy | t | — | 8 (best 0.84) |
| 6YBV | Structure of a human 48S translational initiation complex - EIF2-tc | electron microscopy | t | — | — |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | Y | MET, GTP, MG | — |
| 7D43 | eIF2B-eIF2(aP), aPg complex | electron microscopy | P | — | 3 (best 0.83) |
| 7D43 | EIF2B-EIF2(AP), apg complex | electron microscopy | P | — | — |
| 7F66 | eIF2B-SFSV NSs-1-eIF2 | electron microscopy | S | — | 6 (best 0.86) |
| 7F66 | EIF2B-sfsv nss-1-EIF2 | electron microscopy | S | — | — |
| 7F67 | EIF2B-sfsv nss-2-EIF2 | electron microscopy | S, T | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | t | — | — |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | t | — | — |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | E | — | — |
| 8PHD | Structure of Human Cdc123 bound to domain 3 of eIF2 gamma and ATP | x-ray diffraction | B, D | — | 6 (best 0.49) |
| 8PHV | Structure of Human selenomethionylated Cdc123 bound to domain 3 of eIF2 gamma | x-ray diffraction | B, D | — | 5 (best 0.77) |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | t | GTP, MG, MET | — |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | It | GTP, MG, MET | — |
| 8QZZ | Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452 | x-ray diffraction | A | GNP | 6 (best 0.60) |
| P41091 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2 subunit 3 (P41091) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8PPL chain It against the predicted model P41091: TM-score 1.00, RMSD 0.53 Å
- 8OZ0 chain E against the predicted model P41091: TM-score 0.98, RMSD 1.20 Å
- 8PJ1 chain t against the predicted model P41091: TM-score 0.97, RMSD 1.51 Å
- 8PHD chain D against the predicted model P41091: TM-score 0.96, RMSD 0.91 Å
- 8QZZ chain A against the predicted model P41091: TM-score 0.95, RMSD 1.73 Å
- 8PHD chain B against the predicted model P41091: TM-score 0.95, RMSD 0.97 Å
- 8PHV chain D against the predicted model P41091: TM-score 0.95, RMSD 1.15 Å
- 8PHV chain B against the predicted model P41091: TM-score 0.94, RMSD 1.08 Å
- 6YBV chain t against the predicted model P41091: TM-score 0.94, RMSD 1.93 Å
- 6YBV chain t against the predicted model P41091: TM-score 0.94, RMSD 1.93 Å
Elsewhere
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