Research workbench
EIF2 - EIF2B complex
Analyse EIF2 - EIF2B complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6K71
- Type
- protein
- Length
- 4,244 residues
- Chains
- 13
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor eif-2B subunit alpha; Translation initiation factor eif-2B…
- UniProt
- Q14232, P49770, Q9NR50, Q9UI10, Q13144, P05198, P20042, P41091
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 10 distinct chains · 25% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Translation initiation factor eif-2B subunit alpha | protein | 265 | 45% helix, 11% strand | Q14232 |
| C, D | Translation initiation factor eif-2B subunit beta | protein | 318 | 42% helix, 14% strand | P49770 |
| E | Translation initiation factor eif-2B subunit gamma | protein | 336 | 12% helix, 13% strand | Q9NR50 |
| F | Translation initiation factor eif-2B subunit gamma | protein | 332 | 8% helix, 13% strand | Q9NR50 |
| G, H | Translation initiation factor eif-2B subunit delta | protein | 357 | 36% helix, 11% strand | Q9UI10 |
| I | Translation initiation factor eif-2B subunit epsilon | protein | 421 | 17% helix, 16% strand | Q13144 |
| J | Translation initiation factor eif-2B subunit epsilon | protein | 588 | 29% helix, 13% strand | Q13144 |
| K | Eukaryotic translation initiation factor 2 subunit 1 | protein | 265 | 31% helix, 5% strand | P05198 |
| M | Eukaryotic translation initiation factor 2 subunit 2 | protein | 16 | 81% helix, 0% strand | P20042 |
| P | Eukaryotic translation initiation factor 2 subunit 3 | protein | 406 | 11% helix, 15% strand | P41091 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1066 | 0.87 | 0.88 | 136 | empty |
| 2 | 950 | 0.86 | 0.87 | 125 | empty |
| 3 | 953 | 0.84 | 0.86 | 107 | empty |
| 4 | 392 | 0.83 | 0.90 | 53 | empty |
| 5 | 1085 | 0.82 | 0.83 | 112 | empty |
Interfaces
27 interfaces between chains.
- C–G · 2221 Ų buried · 19 hydrogen bonds · protein-protein
- D–H · 2210 Ų buried · 14 hydrogen bonds · protein-protein
- J–P · 1932 Ų buried · 26 hydrogen bonds · protein-protein
- C–I · 1332 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1246 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6K71 · eIF2 - eIF2B complex · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14232
- Every structure of UniProt P49770
- Every structure of UniProt Q9NR50
- Every structure of UniProt Q9UI10
- Every structure of UniProt Q13144
- Every structure of UniProt P05198
- Every structure of UniProt P20042
- Every structure of UniProt P41091
- Elsewhere: RCSB PDB 6K71 · PDBe 6K71 · UniProt Q14232 · UniProt P49770 · UniProt Q9NR50 · UniProt Q9UI10 · UniProt Q13144 · UniProt P05198 · UniProt P20042 · UniProt P41091
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