UniProt Q9Y210
Short transient receptor potential channel 6 (Q9Y210)
Short transient receptor potential channel 6 (UniProt Q9Y210): 11 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 113 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9Y210
- Protein
- Short transient receptor potential channel 6
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 113 · 6 records with a druggable one
Structures
12 records of Q9Y210 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5YX9 | Cryo-EM structure of human TRPC6 at 3.8A resolution | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 5YX9 | Cryo-EM structure of human TRPC6 at 3.8A resolution | electron microscopy | A, B, C, D | — | — |
| 6UZ8 | Cryo-EM structure of human TRPC6 in complex with agonist am-0883 | electron microscopy | A, D, B, C | SBM, Y01, R0D | — |
| 6UZA | Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473 | electron microscopy | A, B, C, D | R0G, S9Y, SBJ, Y01 | 20 (best 0.84) |
| 6UZA | Cryo-EM structure of human TRPC6 in complex with antagonist am-1473 | electron microscopy | A, B, C, D | R0G, S9Y, SBJ, Y01 | — |
| 7A6U | Cryo-EM structure of the cytoplasmic domain of human TRPC6 | electron microscopy | A, B, C, D | UNX | 18 (best 0.83) |
| 7A6U | Cryo-EM structure of the cytoplasmic domain of human TRPC6 | electron microscopy | A, B, C, D | UNX | — |
| 7DXF | Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state | electron microscopy | A, B, C, D | ZN, W99, Y01, CA, POV, 98R | 20 (best 0.86) |
| 7DXF | Structure of btdm-bound human TRPC6 nanodisc at 2.9 ångström in high calcium state | electron microscopy | A, B, C, D | ZN, W99, Y01, CA, POV, 98R | — |
| 7DXG | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | electron microscopy | A, B, C, D | ZN, CA, Y01, HOR, POV, 98R | 20 (best 0.85) |
| 7DXG | Structure of SAR7334-bound TRPC6 at 2.9 ångström | electron microscopy | A, B, C, D | ZN, CA, Y01, HOR, POV, 98R | — |
| Q9Y210 | AlphaFold monomer V2.0 prediction for short transient receptor potential channel 6 (Q9Y210) | predicted | A | — | 15 (best 0.79) |
Ligands
- Y01 · Cholesterol hemisuccinate · in 7 records
- 98R · [(2S)-2-[(E)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate · in 4 records
- CA · Calcium ion · in 4 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- ZN · Zinc ion · in 4 records
- HOR · 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile · in 2 records
- R0G · 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile · in 2 records
- S9Y · 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium · in 2 records
- SBJ · [(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-octanoyloxy-propan-2-yl] octadecanoate · in 2 records
- UNX · Unknown atom or ion · in 2 records
- W99 · [2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-[(3R, 5S)-3,5-dimethylpiperidin-1-yl]methanone · in 2 records
- R0D · (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2r)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone · in 1 record
- SBM · 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium · in 1 record
Experiment against prediction
- 7A6U chain A against the predicted model Q9Y210: TM-score 0.95, RMSD 1.73 Å
- 7A6U chain A against the predicted model Q9Y210: TM-score 0.95, RMSD 1.73 Å
- 7DXF chain A against the predicted model Q9Y210: TM-score 0.94, RMSD 2.29 Å
- 7DXF chain A against the predicted model Q9Y210: TM-score 0.94, RMSD 2.29 Å
- 6UZ8 chain A against the predicted model Q9Y210: TM-score 0.93, RMSD 2.79 Å
- 7DXG chain A against the predicted model Q9Y210: TM-score 0.91, RMSD 2.99 Å
- 7DXG chain A against the predicted model Q9Y210: TM-score 0.91, RMSD 2.99 Å
- 6UZA chain A against the predicted model Q9Y210: TM-score 0.91, RMSD 3.18 Å
- 6UZA chain A against the predicted model Q9Y210: TM-score 0.91, RMSD 3.18 Å
- 5YX9 chain A against the predicted model Q9Y210: TM-score 0.91, RMSD 3.09 Å
Elsewhere
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