MolNFT v1 · #166734 · protein
Cryo-EM structure of human TRPC6 in complex with agonist am-0883
6UZ8: “Cryo-EM structure of human TRPC6 in complex with agonist am-0883”. Electron microscopy, 3 ligands (Y01, SBM, R0D). MolNFT v1 #166734 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6UZ8
- Type
- protein
- Length
- 2,936 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9Y210
- Ligands
- Y01, SBM, R0D
Structure
electron microscopy · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, B, C | — | protein | 734 | — | Q9Y210 |
Ligands and binding sites
- Y01 · Cholesterol hemisuccinate · ligand · 8 copies · chains A, B, D, C
- SBM · 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium · ligand · 4 copies · chains A, B, D, C
- R0D · (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone · ligand · 4 copies · chains A, D, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6UZ8 · Cryo-EM structure of human TRPC6 in complex with agonist AM-0883 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y210 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 6… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y210
- Elsewhere: RCSB PDB 6UZ8 · PDBe 6UZ8 · UniProt Q9Y210
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