MolNFT v1 · #141133 · protein

Cryo-EM structure of human TRPC6 at 3.8A resolution

5YX9 · Short transient receptor potential channel 6: “Cryo-EM structure of human TRPC6 at 3.8A resolution”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #141133 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 5YX9
Type: protein
Length: 2,700 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Short transient receptor potential channel 6
UniProt: Q9Y210
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Short transient receptor potential channel 6	protein	675	68% helix, 0% strand	Q9Y210

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	811	0.84	0.87	81	empty
2	666	0.83	0.88	80	empty
3	430	0.82	0.90	65	empty
4	513	0.81	0.86	66	empty
5	340	0.80	0.90	55	empty

Interfaces

6 interfaces between chains.

C–D · 4078 Å² buried · 14 hydrogen bonds · protein-protein
A–D · 4077 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 4073 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 4069 Å² buried · 14 hydrogen bonds · protein-protein
B–D · 43 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5YX9 · Cryo-EM structure of human TRPC6 at 3.8A resolution · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y210 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 6… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y210
Elsewhere: RCSB PDB 5YX9 · PDBe 5YX9 · UniProt Q9Y210

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