MolNFT v1 · #172577 · protein
Cryo-EM structure of the cytoplasmic domain of human TRPC6
7A6U · Short transient receptor potential channel 6: “Cryo-EM structure of the cytoplasmic domain of human TRPC6”. Electron microscopy, 1 ligand (UNX), 18 pockets (best druggability 0.83). MolNFT v1 #172577 on GenesisL1: 3D structure…
- PDB
- 7A6U
- Type
- protein
- Length
- 1,328 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Short transient receptor potential channel 6
- UniProt
- Q9Y210
- Ligands
- UNX
- Pockets
- 18 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 64% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Short transient receptor potential channel 6 | protein | 332 | 64% helix, 1% strand | Q9Y210 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1015 | 0.83 | 0.84 | 99 | empty |
| 2 | 977 | 0.83 | 0.84 | 93 | empty |
| 3 | 1035 | 0.82 | 0.83 | 87 | empty |
| 4 | 1154 | 0.82 | 0.83 | 98 | empty |
| 5 | 628 | 0.76 | 0.82 | 63 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2254 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 2216 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 2207 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 2162 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 78 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7A6U · Cryo-EM structure of the cytoplasmic domain of human TRPC6 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y210 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 6… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y210
- Elsewhere: RCSB PDB 7A6U · PDBe 7A6U · UniProt Q9Y210
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