Structure of btdm-bound human TRPC6 nanodisc at 2.9 ångström in high calcium state

Structure

electron microscopy · 1 distinct chain.

Ligands and binding sites

• Y01 · Cholesterol hemisuccinate · ligand · 12 copies · chains A, B, C, D
• W99 · [2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-[(3R, 5S)-3,5-dimethylpiperidin-1-yl]methanone · ligand · 4 copies · chains A, D, B, C
• POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 4 copies · chains A, B, D, C
• 98R · [(2S)-2-[(E)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate · ligand · 4 copies · chains A, D, B, C
• CA · Calcium ion · metal · 12 copies · chains A, B, C, D
• ZN · Zinc ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7DXF · Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y210 · AlphaFold monomer V2.0 prediction for short transient receptor potential channel 6… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y210
• Elsewhere: RCSB PDB 7DXF · PDBe 7DXF · UniProt Q9Y210