GL1X · GenesisL1 explorer

Ligand · R0G

R0G · 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile

R0G, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile (C21 H23 N3 O, 333.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within…

Component
R0G
Formula
C21 H23 N3 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

R0G in 2 structures; the first of them:

  • 6UZA · Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473 · R0G A1001 · binds LYS442, HIS446, ALA447, ALA508, GLU509, GLU512, ASN527, ASP530 and 7 more
  • 6UZA · Cryo-EM structure of human TRPC6 in complex with antagonist am-1473 · R0G A1001 · binds LYS442, HIS446, GLU509, GLU512, ARG609, TYR612, ILE613, SER752 and 2 more

Residues it binds most

GLU 8, ARG 8, TYR 8, ALA 4, HIS 8, ILE 8, LYS 8, SER 8, ASN 4, ASP 4 (residue and the binding sites it lines).

Found with

  • S9Y · 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium
  • SBJ · [(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-octanoyloxy-propan-2-yl] octadecanoate
  • Y01 · Cholesterol hemisuccinate

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