UniProt Q9UL62
Short transient receptor potential channel 5 (Q9UL62)
Short transient receptor potential channel 5 (UniProt Q9UL62): 14 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 184 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9UL62
- Protein
- Short transient receptor potential channel 5
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 184 · 10 records with a druggable one
Structures
15 records of Q9UL62 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YSN | Human TRPC5 in complex with Pico145 (HC-608) | electron microscopy | A, B, C, D | PJQ | 20 (best 0.84) |
| 6YSN | Human TRPC5 in complex with PICO145 (hc-608) | electron microscopy | A, B, C, D | PJQ | — |
| 7D4P | Structure of human TRPC5 in complex with clemizole | electron microscopy | A, B, C, D | GX0, PTY, POV, Y01, ZN, CA | 20 (best 0.87) |
| 7D4P | Structure of human TRPC5 in complex with clemizole | electron microscopy | A, B, C, D | GX0, PTY, POV, Y01, ZN, CA | — |
| 7D4Q | Structure of human TRPC5 in complex with HC-070 | electron microscopy | A, B, C, D | PTY, POV, Y01, ZN, CA, GWR | 20 (best 0.86) |
| 7D4Q | Structure of human TRPC5 in complex with hc-070 | electron microscopy | A, B, C, D | PTY, POV, Y01, ZN, CA, GWR | — |
| 7E4T | Human TRPC5 apo state structure at 3 angstrom | electron microscopy | A, B, C, D | PTY, POV, Y01, ZN, CA, YZY | 20 (best 0.84) |
| 7E4T | Human TRPC5 apo state structure at 3 ångström | electron microscopy | A, B, C, D | PTY, POV, Y01, ZN, CA, YZY | — |
| 7WDB | Human TRPC5 channel in complex with riluzole | electron microscopy | A, B, C, D | POV, Y01, ZN, CA, 657, PTY | 20 (best 0.85) |
| 7WDB | Human TRPC5 channel in complex with riluzole | electron microscopy | A, B, C, D | POV, Y01, ZN, CA, 657, PTY | — |
| 7X6C | Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1 | electron microscopy | C, A, B, D | PTY, POV, Y01, ZN, CA, YZY | 20 (best 0.86) |
| 7X6I | Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1 | electron microscopy | A, B, C, D | PTY, Y01, ZN, CA, YZY | 16 (best 0.84) |
| 8GVW | Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2 | electron microscopy | A, B, C, D | PTY, POV, Y01, ZN, CA, YZY | 20 (best 0.85) |
| 8GVX | Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2 | electron microscopy | B, A, C, D | PTY, Y01, ZN, CA, YZY | 17 (best 0.85) |
| Q9UL62 | AlphaFold monomer V2.0 prediction for short transient receptor potential channel 5 (Q9UL62) | predicted | A | — | 11 (best 0.84) |
Ligands
- CA · Calcium ion · in 12 records
- PTY · Phosphatidylethanolamine · in 12 records
- Y01 · Cholesterol hemisuccinate · in 12 records
- ZN · Zinc ion · in 12 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 10 records
- YZY · (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate · in 8 records
- 657 · 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine · in 2 records
- 7OC · [3-[(~{E})-octadec-10-enoyl]oxy-2-oxidanyl-propyl] (~{E})-octadec-10-enoate · in 2 records
- GWR · 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione · in 2 records
- GX0 · 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl) benzimidazole · in 2 records
- PJQ · 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy) phenoxy]purine-2,6-dione · in 2 records
Experiment against prediction
- 7D4P chain D against the predicted model Q9UL62: TM-score 0.99, RMSD 0.98 Å
- 7D4P chain A against the predicted model Q9UL62: TM-score 0.99, RMSD 0.98 Å
- 7D4P chain A against the predicted model Q9UL62: TM-score 0.99, RMSD 0.98 Å
- 7D4P chain C against the predicted model Q9UL62: TM-score 0.99, RMSD 0.98 Å
- 7D4P chain B against the predicted model Q9UL62: TM-score 0.99, RMSD 0.98 Å
- 7WDB chain A against the predicted model Q9UL62: TM-score 0.99, RMSD 0.98 Å
- 7WDB chain A against the predicted model Q9UL62: TM-score 0.99, RMSD 0.98 Å
- 7D4Q chain A against the predicted model Q9UL62: TM-score 0.99, RMSD 0.99 Å
- 7D4Q chain A against the predicted model Q9UL62: TM-score 0.99, RMSD 0.99 Å
- 7E4T chain A against the predicted model Q9UL62: TM-score 0.99, RMSD 0.99 Å
Elsewhere
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