YZY · (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate

Binding sites

YZY in 8 structures; the first of them:

• 7D4P · Structure of human TRPC5 in complex with clemizole · YZY A807 · binds LEU514, PHE520, LEU521, TYR524, LEU528, ARG557, PHE569, LEU572 and 16 more
• 7E4T · Human TRPC5 apo state structure at 3 angstrom · YZY A806 · binds LEU514, LEU521, TYR524, CYS525, LEU528, LEU572, GLN573, PHE576 and 11 more
• 7X6C · Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1 · YZY C806 · binds VAL527, PHE599, ALA602, THR603, GLY606, THR607, VAL610, ILE611 and 14 more
• 7X6I · Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits… · YZY A805 · binds LEU510, LEU514, LEU521, TYR524, CYS525, LEU528, PHE569, LEU572 and 12 more
• 8GVW · Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2 · YZY A806 · binds LEU514, LEU521, TYR524, LEU528, PHE569, LEU572, GLN573, PHE576 and 10 more
• 8GVX · Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits… · YZY B805 · binds LEU510, LEU514, LEU521, TYR524, CYS525, LEU528, PHE569, LEU572 and 12 more
• 7D4P · Structure of human TRPC5 in complex with clemizole · YZY A807 · binds LEU514, LEU521, TYR524, LEU528, PHE569, GLN573, PHE576, TRP577 and 8 more
• 7E4T · Human TRPC5 apo state structure at 3 ångström · YZY A806 · binds LEU521, TYR524, LEU528, GLN573, PHE576, TRP577, PHE599, VAL610 and 3 more

Residues it binds most

LEU 32, PHE 32, VAL 32, THR 28, ILE 32, GLN 32, TRP 32, TYR 32, ALA 28, GLY 24 (residue and the binding sites it lines).

Found with

• PTY · Phosphatidylethanolamine
• Y01 · Cholesterol hemisuccinate
• CA · Calcium ion
• ZN · Zinc ion
• POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
• GTP · Guanosine-5'-triphosphate
• GX0 · 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl) benzimidazole