MolNFT v1 · #175887 · protein
Structure of human TRPC5 in complex with hc-070
7D4Q · Short transient receptor potential channel 5: “Structure of human TRPC5 in complex with hc-070”. Electron microscopy, 6 ligands (PTY, POV, Y01), 20 pockets (best druggability 0.86). MolNFT v1 #175887 on GenesisL1: 3D structure…
- PDB
- 7D4Q
- Type
- protein
- Length
- 2,672 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Short transient receptor potential channel 5
- UniProt
- Q9UL62
- Ligands
- PTY, POV, Y01, GWR, ZN, CA
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 68% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Short transient receptor potential channel 5 | protein | 668 | 68% helix, 1% strand | Q9UL62 |
Ligands and binding sites
- PTY · Phosphatidylethanolamine · ligand · 4 copies · chains A, D, B, C
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 4 copies · chains A, B, C, D
- Y01 · Cholesterol hemisuccinate · ligand · 4 copies · chains A, D, B, C
- GWR · 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione · ligand · 4 copies · chains A, D, B, C
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
- CA · Calcium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1187 | 0.86 | 0.86 | 88 | empty |
| 2 | 1088 | 0.83 | 0.84 | 100 | empty |
| 3 | 1125 | 0.83 | 0.83 | 99 | empty |
| 4 | 1099 | 0.82 | 0.83 | 99 | empty |
| 5 | 1188 | 0.82 | 0.83 | 99 | empty |
Interfaces
6 interfaces between chains.
- A–D · 5074 Ų buried · 33 hydrogen bonds · protein-protein
- B–C · 5066 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 5063 Ų buried · 33 hydrogen bonds · protein-protein
- C–D · 5057 Ų buried · 33 hydrogen bonds · protein-protein
- A–C · 99 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UL62
- Elsewhere: RCSB PDB 7D4Q · PDBe 7D4Q · UniProt Q9UL62
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.