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Ligand · GWR

GWR · 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione

GWR, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione (C22 H20 Cl2 N4 O4, 475.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
GWR
Formula
C22 H20 Cl2 N4 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

GWR in 2 structures; the first of them:

  • 7D4Q · Structure of human TRPC5 in complex with HC-070 · GWR A806 · binds LEU521, CYS525, LEU528, ARG557, PHE569, LEU572, GLN573, PHE576 and 7 more
  • 7D4Q · Structure of human TRPC5 in complex with hc-070 · GWR A806 · binds LEU521, CYS525, ARG557, PHE569, LEU572, GLN573, PHE576, TRP577 and 5 more

Residues it binds most

PHE 8, LEU 8, THR 8, ALA 8, ARG 8, CYS 8, GLN 8, GLY 8, TRP 8, VAL 4 (residue and the binding sites it lines).

Found with

  • POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
  • PTY · Phosphatidylethanolamine
  • Y01 · Cholesterol hemisuccinate
  • CA · Calcium ion
  • ZN · Zinc ion

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