Ligand · PJQ
PJQ · 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy) phenoxy]purine-2,6-dione
PJQ, 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy) phenoxy]purine-2,6-dione (C23 H20 Cl F3 N4 O5, 524.9 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding…
- Component
- PJQ
- Formula
- C23 H20 Cl F3 N4 O5
- Class
- ligand
- Structures
- 3
- PDB entries
- 2
Binding sites
PJQ in 3 structures; the first of them:
- 6YSN · Human TRPC5 in complex with Pico145 (HC-608) · PJQ A901 · binds LEU521, TYR524, CYS525, LEU528, ARG557, PHE569, LEU572, GLN573 and 9 more
- 8WPM · Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145 · PJQ A801 · binds LEU541, PHE544, LEU545, LEU548, PHE575, ILE588, CYS591, PHE592 and 10 more
- 6YSN · Human TRPC5 in complex with PICO145 (hc-608) · PJQ A901 · binds LEU521, TYR524, CYS525, PHE569, LEU572, GLN573, PHE576, TRP577 and 5 more
Residues it binds most
PHE 12, LEU 12, THR 12, VAL 8, ALA 12, CYS 12, GLY 12, TRP 12, GLN 11, TYR 11 (residue and the binding sites it lines).
Found with
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