UniProt Q9UBS5
Gamma-aminobutyric acid type B receptor subunit 1 (Q9UBS5)
Gamma-aminobutyric acid type B receptor subunit 1 (UniProt Q9UBS5): 37 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9UBS5
- Protein
- Gamma-aminobutyric acid type B receptor subunit 1
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 30 · 3 records with a druggable one
Structures
38 records of Q9UBS5 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MQE | Crystal structure of the extracellular domain of human GABA(B) receptor in the apo form | x-ray diffraction | A | — | — |
| 4MQE | Crystal structure of the extracellular domain of human GABA(B) receptor in the apo form | x-ray diffraction | A | — | — |
| 4MQF | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MQF | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MR7 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MR7 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MR8 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MR8 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MR9 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MR9 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MRM | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MRM | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MS1 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MS1 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | A | — | — |
| 4MS3 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the endogenous… | x-ray diffraction | A | — | — |
| 4MS3 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the endogenous… | x-ray diffraction | A | — | — |
| 4MS4 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist… | x-ray diffraction | A | — | — |
| 4MS4 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist… | x-ray diffraction | A | — | — |
| 4PAS | Heterodimeric coiled-coil structure of human GABA(B) receptor | x-ray diffraction | A | — | — |
| 4PAS | Heterodimeric coiled-coil structure of human GABA(B) receptor | x-ray diffraction | A | — | — |
| 6HKC | Solution structure of the sushi 1 domain of GABABR1A | solution nmr | A | — | — |
| 6UO8 | Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator… | electron microscopy | A | NAG, QD7, QDA | — |
| 6UO9 | Human metabotropic GABA(B) receptor bound to agonist SKF97541 in its intermediate state 2 | electron microscopy | A | NAG, QD7 | — |
| 6UOA | Human metabotropic GABA(B) receptor in its intermediate state 1 | electron microscopy | A | NAG | 8 (best 0.89) |
| 6UOA | Human metabotropic GABA(B) receptor in its intermediate state 1 | electron microscopy | A | NAG | — |
| 6VJM | Human metabotropic GABA(B) receptor in its apo state | electron microscopy | A | NAG | — |
| 6W2X | Cryoem structure of inactive gabab heterodimer | electron microscopy | A | NAG, L9Q, SGG, MG | — |
| 6W2Y | CryoEM Structure of GABAB1b Homodimer | electron microscopy | A, B | NAG, MG, L9Q, SGG | 16 (best 0.86) |
| 6W2Y | Cryoem structure of GABAB1B homodimer | electron microscopy | A, B | NAG, MG, L9Q, SGG | — |
| 6WIV | Structure of human GABA(B) receptor in an inactive state | electron microscopy | A | NAG, CA, U3G, CLR | 6 (best 0.86) |
| 6WIV | Structure of human GABA(B) receptor in an inactive state | electron microscopy | A | NAG, CA, U3G, CLR | — |
| 7C7Q | Cryo-EM structure of the BACLOFEN/BHFF-bound human GABA(B) receptor in active state | electron microscopy | A | NAG, FN0, 2C0 | — |
| 7C7S | Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state. | electron microscopy | A | NAG, 2BV | — |
| 7CA3 | Cryo-EM structure of human GABA(B) receptor bound to the positive allosteric modulator rac-bhff | electron microscopy | A | CLR, FN0 | — |
| 7CA5 | Cryo-EM structure of human GABA(B) receptor in apo state | electron microscopy | A | — | — |
| 7CUM | Cryo-EM structure of human GABA(B) receptor bound to the antagonist CGP54626 | electron microscopy | A | 2BV, UNL, CLR | — |
| 7EB2 | Cryo-EM structure of human GABA(B) receptor-gi protein complex | electron microscopy | C | 2C0, FN0 | — |
| Q9UBS5 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid type B receptor subunit 1 (Q9UBS5) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 12 records
- CLR · Cholesterol · in 4 records
- FN0 · (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one · in 3 records
- L9Q · (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 3 records
- MG · Magnesium ion · in 3 records
- SGG · [(2~{S})-3-[[(1~{S})-1-(3,4-dichlorophenyl) ethyl]amino]-2-oxidanyl-propyl]-(phenylmethyl) phosphinic acid · in 3 records
- 2BV · (R)-(cyclohexylmethyl)[(2s)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid · in 2 records
- 2C0 · Baclofen · in 2 records
- CA · Calcium ion · in 2 records
- QD7 · (R)-(3-aminopropyl)methylphosphinic acid · in 2 records
- U3G · (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-{[(9Z)-octadec-9-enoyl]oxy}propyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate · in 2 records
- QDA · N~4~,N~6~-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine · in 1 record
- UNL · Unknown ligand · in 1 record
Experiment against prediction
- 4MR9 chain A against the predicted model Q9UBS5: TM-score 0.99, RMSD 0.91 Å
- 4MR9 chain A against the predicted model Q9UBS5: TM-score 0.99, RMSD 0.91 Å
- 4MR7 chain A against the predicted model Q9UBS5: TM-score 0.98, RMSD 0.98 Å
- 4MR7 chain A against the predicted model Q9UBS5: TM-score 0.98, RMSD 0.98 Å
- 4MS1 chain A against the predicted model Q9UBS5: TM-score 0.98, RMSD 1.18 Å
- 4MS1 chain A against the predicted model Q9UBS5: TM-score 0.98, RMSD 1.18 Å
- 4MR8 chain A against the predicted model Q9UBS5: TM-score 0.97, RMSD 1.19 Å
- 4MR8 chain A against the predicted model Q9UBS5: TM-score 0.97, RMSD 1.19 Å
- 4MQE chain A against the predicted model Q9UBS5: TM-score 0.97, RMSD 1.23 Å
- 4MQE chain A against the predicted model Q9UBS5: TM-score 0.97, RMSD 1.23 Å
Elsewhere
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