MolNFT v1 · #174905 · protein
Cryo-EM structure of human GABA(B) receptor in apo state
7CA5 · Gamma-aminobutyric acid type B receptor subunit 1: “Cryo-EM structure of human GABA(B) receptor in apo state”. Electron microscopy, 14 pockets (best druggability 0.78). MolNFT v1 #174905 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7CA5
- Type
- protein
- Length
- 1,315 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric acid type B receptor subunit 1; Gamma-aminobutyric acid type B…
- UniProt
- Q9UBS5, O75899
- Pockets
- 14 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma-aminobutyric acid type B receptor subunit 1 | protein | 660 | 50% helix, 8% strand | Q9UBS5 |
| B | Gamma-aminobutyric acid type B receptor subunit 2 | protein | 655 | 50% helix, 9% strand | O75899 |
Pockets
14 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 576 | 0.78 | 0.84 | 73 | empty |
| 2 | 463 | 0.76 | 0.85 | 65 | empty |
| 3 | 710 | 0.76 | 0.81 | 77 | empty |
| 4 | 553 | 0.75 | 0.83 | 96 | empty |
| 5 | 437 | 0.75 | 0.85 | 62 | empty |
Interfaces
1 interface between chains.
- A–B · 159 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7CA5 · Cryo-EM structure of human GABA(B) receptor in apo state · the same entry in another collection · chain A against A, TM-score 1.00
- O75899 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid type B receptor subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.91
- Q9UBS5 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid type B receptor subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBS5
- Every structure of UniProt O75899
- Elsewhere: RCSB PDB 7CA5 · PDBe 7CA5 · UniProt Q9UBS5 · UniProt O75899
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