UniProt O75899
Gamma-aminobutyric acid type B receptor subunit 2 (O75899)
Gamma-aminobutyric acid type B receptor subunit 2 (UniProt O75899): 41 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O75899
- Protein
- Gamma-aminobutyric acid type B receptor subunit 2
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 9 · 1 record with a druggable one
Structures
42 records of O75899 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4F11 | Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 | x-ray diffraction | A | — | — |
| 4F11 | Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 | x-ray diffraction | A | — | — |
| 4F12 | Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 | x-ray diffraction | A | — | — |
| 4F12 | Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 | x-ray diffraction | A | — | — |
| 4MQE | Crystal structure of the extracellular domain of human GABA(B) receptor in the apo form | x-ray diffraction | B | — | — |
| 4MQE | Crystal structure of the extracellular domain of human GABA(B) receptor in the apo form | x-ray diffraction | B | — | — |
| 4MQF | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MQF | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MR7 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MR7 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MR8 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MR8 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MR9 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MR9 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MRM | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MRM | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MS1 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MS1 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist… | x-ray diffraction | B | — | — |
| 4MS3 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the endogenous… | x-ray diffraction | B | — | — |
| 4MS3 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the endogenous… | x-ray diffraction | B | — | — |
| 4MS4 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist… | x-ray diffraction | B | — | — |
| 4MS4 | Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist… | x-ray diffraction | B | — | — |
| 4PAS | Heterodimeric coiled-coil structure of human GABA(B) receptor | x-ray diffraction | B | — | — |
| 4PAS | Heterodimeric coiled-coil structure of human GABA(B) receptor | x-ray diffraction | B | — | — |
| 6M8R | Crystal structure of the KCTD16 BTB domain in complex with GABAB2 peptide | x-ray diffraction | K, L | — | — |
| 6M8R | Crystal structure of the KCTD16 btb domain in complex with GABAB2 peptide | x-ray diffraction | K, L | — | — |
| 6OCP | Crystal structure of a human GABAB receptor peptide bound to KCTD16 T1 | x-ray diffraction | P, Q, R | — | — |
| 6OCP | Crystal structure of a human gabab receptor peptide bound to KCTD16 T1 | x-ray diffraction | P, Q, R | — | — |
| 6UO8 | Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator… | electron microscopy | B | NAG, QDA | — |
| 6UO9 | Human metabotropic GABA(B) receptor bound to agonist SKF97541 in its intermediate state 2 | electron microscopy | B | NAG | — |
| 6UOA | Human metabotropic GABA(B) receptor in its intermediate state 1 | electron microscopy | B | NAG | 9 (best 0.85) |
| 6UOA | Human metabotropic GABA(B) receptor in its intermediate state 1 | electron microscopy | B | NAG | — |
| 6VJM | Human metabotropic GABA(B) receptor in its apo state | electron microscopy | B | NAG | — |
| 6W2X | Cryoem structure of inactive gabab heterodimer | electron microscopy | B | NAG, L9Q | — |
| 6WIV | Structure of human GABA(B) receptor in an inactive state | electron microscopy | B | CLR, NAG, U3D | — |
| 7C7Q | Cryo-EM structure of the BACLOFEN/BHFF-bound human GABA(B) receptor in active state | electron microscopy | B | FN0, NAG | — |
| 7C7S | Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state. | electron microscopy | B | NAG | — |
| 7CA3 | Cryo-EM structure of human GABA(B) receptor bound to the positive allosteric modulator rac-bhff | electron microscopy | B | CLR, FN0 | — |
| 7CA5 | Cryo-EM structure of human GABA(B) receptor in apo state | electron microscopy | B | — | — |
| 7CUM | Cryo-EM structure of human GABA(B) receptor bound to the antagonist CGP54626 | electron microscopy | B | CLR, UNL | — |
| 7EB2 | Cryo-EM structure of human GABA(B) receptor-gi protein complex | electron microscopy | D | FN0 | — |
| O75899 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid type B receptor subunit 2 (O75899) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 9 records
- CLR · Cholesterol · in 3 records
- FN0 · (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one · in 3 records
- L9Q · (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · in 1 record
- QDA · N~4~,N~6~-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine · in 1 record
- U3D · [(2R)-3-[(Z)-icos-11-enoyl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate · in 1 record
- UNL · Unknown ligand · in 1 record
Experiment against prediction
- 4MR8 chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MR8 chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MS1 chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MS1 chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MRM chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MRM chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MQE chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MQE chain B against the predicted model O75899: TM-score 0.99, RMSD 0.60 Å
- 4MR9 chain B against the predicted model O75899: TM-score 0.99, RMSD 0.62 Å
- 4MR9 chain B against the predicted model O75899: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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