MolNFT v1 · #174903 · protein
Cryo-EM structure of human GABA(B) receptor bound to the positive allosteric modulator rac-bhff
7CA3: “Cryo-EM structure of human GABA(B) receptor bound to the positive allosteric modulator rac-bhff”. Electron microscopy, 2 ligands (CLR, FN0). MolNFT v1 #174903 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7CA3
- Type
- protein
- Length
- 1,350 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9UBS5, O75899
- Ligands
- CLR, FN0
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 669 | — | Q9UBS5 |
| B | — | protein | 681 | — | O75899 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 3 copies · chains A, B
- FN0 · (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7CA3 · Cryo-EM structure of human GABA(B) receptor bound to the positive allosteric modulator… · the same entry in another collection · chain A against A, TM-score 1.00
- O75899 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid type B receptor subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.81
- Q9UBS5 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid type B receptor subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBS5
- Every structure of UniProt O75899
- Elsewhere: RCSB PDB 7CA3 · PDBe 7CA3 · UniProt Q9UBS5 · UniProt O75899
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