MolNFT v1 · #159052 · protein

Crystal structure of a human gabab receptor peptide bound to KCTD16 T1

6OCP · BTB/POZ domain-containing protein KCTD16: “Crystal structure of a human gabab receptor peptide bound to KCTD16 T1”. X-ray diffraction, 14 pockets (best druggability 0.69). MolNFT v1 #159052 on GenesisL1: 3D structure, binding sites…

PDB: 6OCP
Type: protein
Length: 1,466 residues
Chains: 18
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BTB/POZ domain-containing protein KCTD16; Gamma-aminobutyric acid type B receptor subunit…
UniProt: Q68DU8, O75899
Pockets: 14 · best druggability 0.69

Structure

x-ray diffraction · 14 distinct chains · 38% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BTB/POZ domain-containing protein KCTD16	protein	96	38% helix, 17% strand	Q68DU8
B	BTB/POZ domain-containing protein KCTD16	protein	99	36% helix, 16% strand	Q68DU8
C, M, O	BTB/POZ domain-containing protein KCTD16	protein	95	38% helix, 17% strand	Q68DU8
D, L	BTB/POZ domain-containing protein KCTD16	protein	96	38% helix, 17% strand	Q68DU8
E	BTB/POZ domain-containing protein KCTD16	protein	97	38% helix, 16% strand	Q68DU8
F	BTB/POZ domain-containing protein KCTD16	protein	95	41% helix, 17% strand	Q68DU8
G	BTB/POZ domain-containing protein KCTD16	protein	97	37% helix, 16% strand	Q68DU8
H	BTB/POZ domain-containing protein KCTD16	protein	94	37% helix, 17% strand	Q68DU8
I	BTB/POZ domain-containing protein KCTD16	protein	92	39% helix, 17% strand	Q68DU8
J	BTB/POZ domain-containing protein KCTD16	protein	93	38% helix, 17% strand	Q68DU8
K	BTB/POZ domain-containing protein KCTD16	protein	94	41% helix, 17% strand	Q68DU8
N	BTB/POZ domain-containing protein KCTD16	protein	93	40% helix, 17% strand	Q68DU8
P	Gamma-aminobutyric acid type B receptor subunit 2	protein	15	27% helix, 7% strand	O75899
Q, R	Gamma-aminobutyric acid type B receptor subunit 2	protein	12	33% helix, 0% strand	O75899

Pockets

14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	276	0.69	0.84	47	empty
2	647	0.65	0.75	66	empty
3	585	0.64	0.75	74	empty
4	498	0.61	0.75	71	empty
5	118	0.49	0.80	27	empty

Interfaces

30 interfaces between chains.

K–L · 942 Å² buried · 26 hydrogen bonds · protein-protein
F–G · 932 Å² buried · 24 hydrogen bonds · protein-protein
D–E · 902 Å² buried · 22 hydrogen bonds · protein-protein
I–J · 863 Å² buried · 21 hydrogen bonds · protein-protein
L–M · 860 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

6OCP · Crystal structure of a human GABAB receptor peptide bound to KCTD16 T1 · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q68DU8
Every structure of UniProt O75899
Elsewhere: RCSB PDB 6OCP · PDBe 6OCP · UniProt Q68DU8 · UniProt O75899

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