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Ligand · 2BV

2BV · (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid

2BV, (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid (C18 H28 Cl2 N O3 P, 408.3 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site…

Component
2BV
Formula
C18 H28 Cl2 N O3 P
Class
ligand
Structures
4
PDB entries
2

Binding sites

2BV in 4 structures; the first of them:

  • 7C7S · Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state. · 2BV A1006 · binds GLY181, TRP182, CYS246, SER247, GLY268, SER269, SER270, SER271 and 5 more
  • 7CUM · Cryo-EM structure of human GABA(B) receptor bound to the antagonist CGP54626 · 2BV A1001 · binds GLY181, TRP182, CYS246, SER247, GLY268, SER270, HIS287, TRP395 and 1 more
  • 7C7S · Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state. · 2BV A1006 · binds GLY181, TRP182, CYS246, SER247, GLY268, SER269, SER270, HIS287 and 2 more
  • 7CUM · Cryo-EM structure of human GABA(B) receptor bound to the antagonist CGP54626 · 2BV A1001 · binds GLY181, TRP182, CYS246, SER247, GLY268, SER270, HIS287, TRP395 and 1 more

Residues it binds most

SER 4, GLY 4, TRP 4, CYS 4, GLU 4, HIS 4, MET 1, TYR 1 (residue and the binding sites it lines).

Found with

  • CLR · Cholesterol
  • UNL · Unknown ligand
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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