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Ligand · 2C0

2C0 · baclofen

2C0, baclofen (C10 H12 Cl N O2, 213.7 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
2C0
Formula
C10 H12 Cl N O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

2C0 in 4 structures; the first of them:

  • 7C7Q · Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state · 2C0 A1007 · binds TRP182, CYS246, SER247, GLY268, SER269, SER270, HIS287, PHE319 and 6 more
  • 7EB2 · Cryo-EM structure of human GABA(B) receptor-Gi protein complex · 2C0 C1001 · binds TRP182, CYS246, SER247, GLY268, SER270, HIS287, PHE319, PHE366 and 5 more
  • 7C7Q · Cryo-EM structure of the BACLOFEN/BHFF-bound human GABA(B) receptor in active state · 2C0 A1007 · binds TRP182, CYS246, SER247, GLY268, SER270, HIS287, PHE366, TYR367 and 4 more
  • 7EB2 · Cryo-EM structure of human GABA(B) receptor-gi protein complex · 2C0 C1001 · binds TRP182, CYS246, SER247, GLY268, SER270, HIS287, PHE366, TYR367 and 4 more

Residues it binds most

SER 4, TRP 4, TYR 4, PHE 4, CYS 4, GLU 4, GLY 4, HIS 4, ILE 4 (residue and the binding sites it lines).

Found with

  • FN0 · (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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