UniProt Q9H1D0
Transient receptor potential cation channel subfamily V member 6 (Q9H1D0)
Transient receptor potential cation channel subfamily V member 6 (UniProt Q9H1D0): 39 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 589 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9H1D0
- Protein
- Transient receptor potential cation channel subfamily V member 6
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 589 · 30 records with a druggable one
Structures
40 records of Q9H1D0 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BO8 | Cryo-EM structure of human TRPV6 in nanodiscs | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 6BO8 | Cryo-EM structure of human TRPV6 in nanodiscs | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 6BO9 | Cryo-EM structure of human TRPV6 in amphipols | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 6BO9 | Cryo-EM structure of human TRPV6 in amphipols | electron microscopy | A, B, C, D | — | 20 (best 0.84) |
| 6BOA | Cryo-EM structure of human TRPV6-R470E in amphipols | electron microscopy | A, B, C, D | — | 20 (best 0.87) |
| 6BOA | Cryo-EM structure of human TRPV6-R470E in amphipols | electron microscopy | A, B, C, D | — | 20 (best 0.87) |
| 6D7S | Cryo-EM structure of human TRPV6-Y467A in amphipols | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 6D7S | Cryo-EM structure of human TRPV6-Y467A in amphipols | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 6D7T | Cryo-EM structure of human TRPV6-Y467A in complex with 2-Aminoethoxydiphenyl borate (2-APB) | electron microscopy | A, B, C, D | FZ4, CA | 20 (best 0.85) |
| 6D7T | Cryo-EM structure of human TRPV6-Y467A in complex with 2- aminoethoxydiphenyl borate (2-apb) | electron microscopy | A, B, C, D | FZ4, CA | 20 (best 0.85) |
| 6E2F | Cryo-EM structure of human TRPV6 in complex with Calmodulin | electron microscopy | A, B, C, D | CA | 20 (best 0.84) |
| 6E2F | Cryo-EM structure of human TRPV6 in complex with calmodulin | electron microscopy | A, B, C, D | CA | 20 (best 0.84) |
| 7K4A | Cryo-EM structure of human TRPV6 in the open state | electron microscopy | A, B, C, D | Y01, PCW, CA | 20 (best 0.83) |
| 7K4A | Cryo-EM structure of human TRPV6 in the open state | electron microscopy | A, B, C, D | Y01, PCW, CA | — |
| 7K4B | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a | electron microscopy | A, B, C, D | VUG, Y01, PCW, CA | 20 (best 0.85) |
| 7K4B | Cryo-EM structure of human TRPV6 in complex with (4- PHENYLCYCLOHEXYL)PIPERAZINE inhibitor cis-22A | electron microscopy | A, B, C, D | VUG, Y01, PCW, CA | — |
| 7K4C | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor… | electron microscopy | A, B, C, D | 81F, CA | 20 (best 0.84) |
| 7K4C | Cryo-EM structure of human TRPV6 in complex with (4- PHENYLCYCLOHEXYL)PIPERAZINE inhibitor… | electron microscopy | A, B, C, D | 81F, CA | — |
| 7K4D | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG | electron microscopy | A, B, C, D | VUM, CA | 20 (best 0.84) |
| 7K4D | Cryo-EM structure of human TRPV6 in complex with (4- PHENYLCYCLOHEXYL)PIPERAZINE inhibitor 3OG | electron microscopy | A, B, C, D | VUM, CA | — |
| 7K4E | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 30 | electron microscopy | A, B, C, D | VUJ | 20 (best 0.86) |
| 7K4E | Cryo-EM structure of human TRPV6 in complex with (4- PHENYLCYCLOHEXYL)PIPERAZINE inhibitor 30 | electron microscopy | A, B, C, D | VUJ | — |
| 7K4F | Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 31 | electron microscopy | A, B, C, D | 5GK, CA | 20 (best 0.86) |
| 7K4F | Cryo-EM structure of human TRPV6 in complex with (4- PHENYLCYCLOHEXYL)PIPERAZINE inhibitor 31 | electron microscopy | A, B, C, D | 5GK, CA | — |
| 7S88 | Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent | electron microscopy | A, B, C, D | Y01, PCW, POV, CA | 20 (best 0.85) |
| 7S88 | Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent | electron microscopy | A, B, C, D | Y01, PCW, POV, CA | — |
| 7S89 | Open apo-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs | electron microscopy | A, B, C, D | Y01, POV, PCW, CA | 20 (best 0.85) |
| 7S89 | Open apo-state cryo-EM structure of human TRPV6 in CNW11 nanodiscs | electron microscopy | A, B, C, D | Y01, POV, PCW, CA | — |
| 7S8B | Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red | electron microscopy | A, B, C, D | Y01, PCW, POV, CA, R2R | 20 (best 0.86) |
| 7S8B | Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red | electron microscopy | A, B, C, D | Y01, PCW, POV, CA, R2R | — |
| 7S8C | Cryo-EM structure of human TRPV6 in complex with inhibitor econazole | electron microscopy | A, B, C, D | ECL, Y01, POV, CA | 20 (best 0.86) |
| 7S8C | Cryo-EM structure of human TRPV6 in complex with inhibitor econazole | electron microscopy | A, B, C, D | ECL, Y01, POV, CA | — |
| 8FOA | Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein | electron microscopy | A, B, C, D | Y01, POV, ZN, CA, GEN | 20 (best 0.85) |
| 8FOB | Cryo-EM structure of human TRPV6 in the open state | electron microscopy | A, B, C, D | Y01, PCW, POV, CA | 20 (best 0.84) |
| 8SP8 | Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV) | electron microscopy | A, B, C, D | Y01, POV, I8E, CA, CL | 20 (best 0.86) |
| 9CUH | Structure of human full-length ancestral TRPV6 channel in apo open state | electron microscopy | A, B, C, D | Y01, PCW, POV, CA | 20 (best 0.84) |
| 9CUI | Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state | electron microscopy | A, B, C, D | Y01, CLR, PCW, CA | 20 (best 0.85) |
| 9CUJ | Structure of human full-length derived TRPV6 channel in apo open state | electron microscopy | A, B, C, D | Y01, POV, PCW, CA | 20 (best 0.84) |
| 9CUK | Structure of human full-length derived TRPV6 channel in Calmodulin-bound state | electron microscopy | A, B, C, D | Y01, CLR, PCW, CA | 20 (best 0.85) |
| Q9H1D0 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V… | predicted | A | — | 9 (best 0.69) |
Ligands
- CA · Calcium ion · in 29 records
- Y01 · Cholesterol hemisuccinate · in 19 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 15 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 13 records
- 5GK · 5-[(4-{cis-4-[3-(trifluoromethyl) phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one · in 2 records
- 81F · 1-(5-bromopyridin-3-yl)-4-[cis-4-(3-methylphenyl) cyclohexyl]piperazine · in 2 records
- CLR · Cholesterol · in 2 records
- ECL · 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl) ethyl]-1H-imidazole · in 2 records
- FZ4 · 2-aminoethyl diphenylborinate · in 2 records
- R2R · ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) · in 2 records
- VUG · 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(pyridin-3-yl) piperazine · in 2 records
- VUJ · 5-({4-[(1R,4S)-3'-methyl[1,2,3,4-tetrahydro[1,1'-biphenyl]]-4-yl]piperazin-1-yl}methyl)pyridin-2(1H)-one · in 2 records
- VUM · 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl) phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one · in 2 records
- CL · Chloride ion · in 1 record
- GEN · Genistein · in 1 record
- I8E · Tetrahydrocannabivarin · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 7S89 chain A against the predicted model Q9H1D0: TM-score 0.99, RMSD 0.95 Å
- 7S89 chain A against the predicted model Q9H1D0: TM-score 0.99, RMSD 0.95 Å
- 9CUH chain A against the predicted model Q9H1D0: TM-score 0.99, RMSD 0.97 Å
- 7S8C chain A against the predicted model Q9H1D0: TM-score 0.98, RMSD 1.04 Å
- 7S8C chain A against the predicted model Q9H1D0: TM-score 0.98, RMSD 1.04 Å
- 6BO8 chain A against the predicted model Q9H1D0: TM-score 0.98, RMSD 1.06 Å
- 6BO8 chain A against the predicted model Q9H1D0: TM-score 0.98, RMSD 1.06 Å
- 7K4B chain A against the predicted model Q9H1D0: TM-score 0.98, RMSD 1.08 Å
- 7K4B chain A against the predicted model Q9H1D0: TM-score 0.98, RMSD 1.08 Å
- 6BO9 chain A against the predicted model Q9H1D0: TM-score 0.98, RMSD 1.07 Å
Elsewhere
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