MolNFT v1 · #144264 · protein

Cryo-EM structure of human TRPV6-R470E in amphipols

6BOA · Transient receptor potential cation channel subfamily V…: “Cryo-EM structure of human TRPV6-R470E in amphipols”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #144264 on GenesisL1: 3D structure, binding sites…

PDB: 6BOA
Type: protein
Length: 2,372 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 6
UniProt: Q9H1D0
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 1 distinct chain · 53% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 6	protein	593	53% helix, 3% strand	Q9H1D0

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	810	0.87	0.89	87	empty
2	835	0.78	0.81	76	empty
3	853	0.77	0.80	69	empty
4	769	0.76	0.80	61	empty
5	457	0.70	0.80	50	empty

Interfaces

6 interfaces between chains.

A–B · 3557 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 3540 Å² buried · 15 hydrogen bonds · protein-protein
C–D · 3526 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 3512 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 21 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6BOA · Cryo-EM structure of human TRPV6-R470E in amphipols · the same entry in another collection · chain A against A, TM-score 1.00
Q9H1D0 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H1D0
Elsewhere: RCSB PDB 6BOA · PDBe 6BOA · UniProt Q9H1D0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.