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Ligand · VUM

VUM · 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl) phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one

VUM, 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl) phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one (C23 H28 F3 N3 O2, 435.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with…

Component
VUM
Formula
C23 H28 F3 N3 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

VUM in 2 structures; the first of them:

  • 7K4D · Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine… · VUM A701 · binds PRO424, PHE425, LEU428, PHE456, VAL459, LEU460, CYS463, MET466 and 8 more
  • 7K4D · Cryo-EM structure of human TRPV6 in complex with (4- PHENYLCYCLOHEXYL)PIPERAZINE… · VUM A701 · binds PRO424, PHE425, LEU428, PHE456, VAL459, LEU460, CYS463, MET466 and 8 more

Residues it binds most

ILE 10, PHE 8, THR 8, LEU 8, ALA 8, CYS 8, GLN 8, GLY 2, MET 8, PRO 8 (residue and the binding sites it lines).

Found with

  • CA · Calcium ion

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