UniProt Q6WZB0
Alpha-ketoglutarate-dependent L-arginine hydroxylase (Q6WZB0)
Alpha-ketoglutarate-dependent L-arginine hydroxylase (UniProt Q6WZB0), EC 1.14.11.41: 33 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 51 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q6WZB0
- Protein
- Alpha-ketoglutarate-dependent L-arginine hydroxylase
- EC
- 1.14.11.41
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 51 · 11 records with a druggable one
Structures
34 records of Q6WZB0 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WBO | Crystal structure of VioC in complex with L-arginine | x-ray diffraction | A | — | — |
| 2WBO | Crystal structure of vioc in complex with L-arginine | x-ray diffraction | A | — | — |
| 2WBP | Crystal structure of VioC in complex with Fe(II), (2S,3S)- hydroxyarginine, and succinate | x-ray diffraction | A | — | — |
| 2WBP | Crystal structure of vioc in complex with FE(II), (2S,3S)- hydroxyarginine, and succinate | x-ray diffraction | A | — | — |
| 2WBQ | Crystal structure of VioC in complex with (2S,3S)-hydroxyarginine | x-ray diffraction | A | — | — |
| 2WBQ | Crystal structure of vioc in complex with (2S,3S)- hydroxyarginine | x-ray diffraction | A | — | — |
| 6ALM | VioC L-arginine hydroxylase bound to Fe(II), L-arginine, and 2-OXO-GLUTARIC ACID | x-ray diffraction | A | FE2, AKG, ARG | 4 (best 0.77) |
| 6ALM | Vioc L-arginine hydroxylase bound to FE(II), L-arginine, and 2-oxo- glutaric acid | x-ray diffraction | A | FE2, AKG | — |
| 6ALN | VioC L-arginine hydroxylase bound to Fe(II), 3S-hydroxy-L-arginine, and 2OG | x-ray diffraction | A | AKG, FE2 | — |
| 6ALN | Vioc L-arginine hydroxylase bound to FE(II), 3S-hydroxy-L-arginine, and 2OG | x-ray diffraction | A | AKG, FE2 | — |
| 6ALO | VioC L-arginine hydroxylase bound to Fe(II), L-arginine, and a peroxysuccinate intermediate | x-ray diffraction | A | FE2, ARG, OKG | 5 (best 0.75) |
| 6ALO | Vioc L-arginine hydroxylase bound to FE(II), L-arginine, and a peroxysuccinate intermediate | x-ray diffraction | A | FE2, OKG | — |
| 6ALP | VioC L-arginine hydroxylase bound to Fe(II), 3S-hydroxy-L-arginine, and succinate | x-ray diffraction | A | FE2, ZZU | 5 (best 0.75) |
| 6ALP | Vioc L-arginine hydroxylase bound to FE(II), 3S-hydroxy-L-arginine, and succinate | x-ray diffraction | A | FE2 | — |
| 6ALQ | VioC L-arginine hydroxylase bound to Fe(II), L-arginine, and succinate | x-ray diffraction | A | FE2, ARG | 5 (best 0.75) |
| 6ALQ | Vioc L-arginine hydroxylase bound to FE(II), L-arginine, and succinate | x-ray diffraction | A | FE2 | — |
| 6ALR | VioC L-arginine hydroxylase bound to the vanadyl ion, L-arginine, and succinate | x-ray diffraction | A | VVO | — |
| 6ALR | Vioc L-arginine hydroxylase bound to the vanadyl ion, L-arginine, and succinate | x-ray diffraction | A | VVO | — |
| 6DAX | X-ray crystal structure of VioC bound to Fe(II), L-homoarginine, and 2-oxoglutarate | x-ray diffraction | A | AKG, HRG, FE2 | 4 (best 0.77) |
| 6DAX | X-ray crystal structure of vioc bound to FE(II), L-homoarginine, and 2-oxoglutarate | x-ray diffraction | A | AKG, FE2 | — |
| 6DAZ | X-ray crystal structure of VioC bound to Fe(II), 3S-hydroxy-L-homoarginine, and succinate | x-ray diffraction | A | FE2, G3M | 5 (best 0.74) |
| 6DAZ | X-ray crystal structure of vioc bound to FE(II), 3S-hydroxy-L- homoarginine, and succinate | x-ray diffraction | A | FE2, G3M | — |
| 6DB2 | X-ray crystal structure of VioC bound to vanadyl ion, L-homoarginine, and succinate | x-ray diffraction | A | HRG, VVO | 4 (best 0.67) |
| 6DB2 | X-ray crystal structure of vioc bound to vanadyl ion, L-homoarginine, and succinate | x-ray diffraction | A | VVO | — |
| 6MP8 | X-ray crystal structure of VioC bound to Fe(II), D-arginine, and 2-oxoglutarate | x-ray diffraction | A | AKG, FE2, DAR | 3 (best 0.65) |
| 6MP8 | X-ray crystal structure of vioc bound to FE(II), D-arginine, and 2- oxoglutarate | x-ray diffraction | A | AKG, FE2 | — |
| 6MP9 | X-ray crystal structure of VioC bound to Fe(II), 2-oxo-5-guanidinopentanoic acid, and succinate | x-ray diffraction | A | JX7, FE2 | — |
| 6MP9 | X-ray crystal structure of vioc bound to FE(II), 2-oxo-5- guanidinopentanoic acid, and succinate | x-ray diffraction | A | JX7, FE2 | — |
| 6Y0N | Arginine hydroxylase VioC in complex with Arg, 2OG and Fe under anaerobic environment using FT-SSX… | x-ray diffraction | A | ARG, AKG, FE | 5 (best 0.77) |
| 6Y0N | Arginine hydroxylase vioc in complex with arg, 2OG and fe under anaerobic environment using ft-ssx… | x-ray diffraction | A | AKG, FE | — |
| 6Y12 | Arginine hydroxylase VioC in complex with (3S)-OH-Arg, succinate and Fe after oxygen exposure using… | x-ray diffraction | A | FE, ZZU | 6 (best 0.74) |
| 6Y12 | Arginine hydroxylase vioc in complex with (3S)-oh-arg, succinate and fe after oxygen exposure using… | x-ray diffraction | A | FE | — |
| 9EQF | Crystal structure of the L-arginine hydroxylase VioC MeHis316, bound to Fe(II), L-arginine, and… | x-ray diffraction | A | FE2, ARG | 5 (best 0.73) |
| Q6WZB0 | AlphaFold monomer V2.0 prediction for alpha-ketoglutarate-dependent L-arginine hydroxylase (Q6WZB0) | predicted | A | — | — |
Ligands
- FE2 · Fe (II) ion · in 19 records
- AKG · 2-oxoglutaric acid · in 10 records
- ARG · Arginine · in 5 records
- FE · Fe (III) ion · in 4 records
- VVO · oxovanadium(2+) · in 4 records
- G3M · (3S)-N~6~-carbamimidoyl-3-hydroxy-L-lysine · in 2 records
- HRG · L-homoarginine · in 2 records
- JX7 · 5-carbamimidamido-2-oxopentanoic acid · in 2 records
- OKG · 4-peroxy-4-oxobutanoic acid · in 2 records
- ZZU · (2S,3S)-3-hydroxyarginine · in 2 records
- DAR · D-arginine · in 1 record
Experiment against prediction
- 6ALO chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.19 Å
- 6DAZ chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.21 Å
- 6DAZ chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.21 Å
- 6ALQ chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.23 Å
- 6Y12 chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.26 Å
- 6DB2 chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.29 Å
- 6Y0N chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.28 Å
- 9EQF chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.28 Å
- 6MP9 chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.37 Å
- 6MP9 chain A against the predicted model Q6WZB0: TM-score 1.00, RMSD 0.37 Å
Elsewhere
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