UniProt Q15758
Neutral amino acid transporter B(0) (Q15758)
Neutral amino acid transporter B(0) (UniProt Q15758): 34 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 182 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15758
- Protein
- Neutral amino acid transporter B(0)
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 182 · 15 records with a druggable one
Structures
35 records of Q15758 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LLM | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric… | x-ray diffraction | A | NA, ASP, 6Z6 | 4 (best 0.69) |
| 5LLM | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-asp and the allosteric… | x-ray diffraction | A | NA, 6Z6 | — |
| 5LLU | Structure of the thermostabilized EAAT1 cryst-II mutant in complex with L-ASP | x-ray diffraction | A | NA, ASP | 4 (best 0.65) |
| 5LLU | Structure of the thermostabilized EAAT1 cryst-II mutant in complex with L-asp | x-ray diffraction | A | NA | — |
| 5LM4 | Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-ASP and the allosteric… | x-ray diffraction | A | NA, 6Z6 | — |
| 5LM4 | Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-asp and the allosteric… | x-ray diffraction | A | NA, 6Z6 | — |
| 5MJU | Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor… | x-ray diffraction | A | 6Z6, 7O9 | — |
| 5MJU | Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor… | x-ray diffraction | A | 6Z6, 7O9 | — |
| 6GCT | cryo-EM structure of the human neutral amino acid transporter ASCT2 | electron microscopy | A, B, C | GLN | 20 (best 0.87) |
| 6GCT | Cryo-EM structure of the human neutral amino acid transporter ASCT2 | electron microscopy | A, B, C | — | — |
| 6MP6 | Cryo-EM structure of the human neutral amino acid transporter ASCT2 | electron microscopy | A, B, C | NAG | 20 (best 0.86) |
| 6MP6 | Cryo-EM structure of the human neutral amino acid transporter ASCT2 | electron microscopy | A, B, C | NAG | — |
| 6MPB | Cryo-EM structure of the human neutral amino acid transporter ASCT2 | electron microscopy | B, C, A | NAG | — |
| 6MPB | Cryo-EM structure of the human neutral amino acid transporter ASCT2 | electron microscopy | B, C, A | NAG | — |
| 6RVX | Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA | electron microscopy | A, B, C | — | 20 (best 0.88) |
| 6RVX | Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of tboa | electron microscopy | A, B, C | — | — |
| 6RVY | Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate | electron microscopy | A, B, C | — | — |
| 7AWM | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-asp, three sodium ions and… | x-ray diffraction | A | NA, 6Z6 | — |
| 7AWN | Structure of the thermostabilized EAAT1 cryst mutant in complex with rubidium and barium and the… | x-ray diffraction | A | 6Z6, BA, RB | — |
| 7AWP | Structure of the thermostabilized EAAT1 cryst-II mutant in complex with rubidium and barium ions… | x-ray diffraction | A | 6Z6, BA, RB | — |
| 7AWQ | Structure of the thermostabilized EAAT1 cryst-E386Q mutant in complex with L-asp, sodium ions and… | x-ray diffraction | A | NA, 6Z6, BA | — |
| 7BCQ | ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation. | electron microscopy | A, B, C | TG2 | 20 (best 0.88) |
| 7BCQ | ASCT2 in the presence of the inhibitor lc-bpe (position "up") in the outward-open conformation. | electron microscopy | A, B, C | TG2 | — |
| 7BCS | ASCT2 in the presence of the inhibitor lc-bpe (position "down") in the outward-open conformation. | electron microscopy | A, B, C | TJ5 | — |
| 7BCT | ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation. | electron microscopy | A, B, C | — | 20 (best 0.89) |
| 7BCT | ASCT2 in the presence of the inhibitor era-21 in the outward-open conformation. | electron microscopy | A, B, C | — | — |
| 8OUD | Structure of the human neutral amino acid transporter ASCT2 in complex with nanobody 469 | electron microscopy | A, B, C | NA, ALA, Y01 | 20 (best 0.87) |
| 8OUH | Complex of human ASCT2 with Syncytin-1 | electron microscopy | C, A, B | ALA | 20 (best 0.87) |
| 8QRP | ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state… | electron microscopy | B | NA, GLN | 6 (best 0.67) |
| 8QRQ | ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state… | electron microscopy | B | NA, GLN | 5 (best 0.69) |
| 8QRR | ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the outward-facing state… | electron microscopy | B | NA, GLN | 6 (best 0.70) |
| 8QRU | ASCT2 protomer in lipid nanodiscs with bound glutamine and Na+ ions in the intermediate… | electron microscopy | B | GLN | 6 (best 0.62) |
| 8QRV | ASCT2 protomer in lipid nanodiscs under low Na+ concentration in the outward-facing state (OFS) | electron microscopy | B | NA | 5 (best 0.77) |
| 8QRW | ASCT2 protomer in lipid nanodiscs under low Na+ concentration in the intermediate outward-facing… | electron microscopy | B | NA | 6 (best 0.80) |
| Q15758 | AlphaFold monomer V2.0 prediction for neutral amino acid transporter B(0) (Q15758) | predicted | A | — | — |
Ligands
- NA · Sodium ion · in 14 records
- 6Z6 · 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile · in 10 records
- GLN · Glutamine · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- BA · Barium ion · in 3 records
- 7O9 · (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl) phenyl]carbonylamino]phenyl]methoxy]butanedioic acid · in 2 records
- ALA · Alanine · in 2 records
- ASP · Aspartic acid · in 2 records
- RB · Rubidium ion · in 2 records
- TG2 · 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid · in 2 records
- TJ5 · (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 8QRP chain B against the predicted model Q15758: TM-score 0.98, RMSD 1.02 Å
- 8QRR chain B against the predicted model Q15758: TM-score 0.98, RMSD 1.12 Å
- 8QRQ chain B against the predicted model Q15758: TM-score 0.98, RMSD 1.13 Å
- 8QRV chain B against the predicted model Q15758: TM-score 0.98, RMSD 1.20 Å
- 8OUH chain A against the predicted model Q15758: TM-score 0.97, RMSD 1.32 Å
- 5LLU chain A against the predicted model P43003: TM-score 0.97, RMSD 1.35 Å
- 5LLU chain A against the predicted model P43003: TM-score 0.97, RMSD 1.35 Å
- 5LM4 chain A against the predicted model P43003: TM-score 0.97, RMSD 1.34 Å
- 5LM4 chain A against the predicted model P43003: TM-score 0.97, RMSD 1.34 Å
- 5LLM chain A against the predicted model P43003: TM-score 0.96, RMSD 1.63 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.