MolNFT v1 · #173848 · protein
ASCT2 in the presence of the inhibitor era-21 in the outward-open conformation.
7BCT · Neutral amino acid transporter B(0): “ASCT2 in the presence of the inhibitor era-21 in the outward-open conformation.”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #173848 on GenesisL1: 3D structure, binding…
- PDB
- 7BCT
- Type
- protein
- Length
- 1,326 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutral amino acid transporter B(0)
- UniProt
- Q15758
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 1 distinct chain · 73% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Neutral amino acid transporter B(0) | protein | 442 | 73% helix, 4% strand | Q15758 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1008 | 0.89 | 0.88 | 45 | empty |
| 2 | 1058 | 0.77 | 0.79 | 112 | empty |
| 3 | 837 | 0.74 | 0.78 | 72 | empty |
| 4 | 764 | 0.74 | 0.79 | 73 | empty |
| 5 | 242 | 0.62 | 0.81 | 50 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1384 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1383 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 1370 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 7BCT · ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation. · the same entry in another collection · chain A against A, TM-score 1.00
- Q15758 · AlphaFold monomer V2.0 prediction for neutral amino acid transporter B(0) (Q15758) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15758
- Elsewhere: RCSB PDB 7BCT · PDBe 7BCT · UniProt Q15758
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