MolNFT v1 · #157125 · protein
Cryo-EM structure of the human neutral amino acid transporter ASCT2
6MP6 · Neutral amino acid transporter B(0): “Cryo-EM structure of the human neutral amino acid transporter ASCT2”. Electron microscopy, 1 ligand (NAG), 20 pockets (best druggability 0.86). MolNFT v1 #157125 on GenesisL1: 3D structure…
- PDB
- 6MP6
- Type
- protein
- Length
- 1,338 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutral amino acid transporter B(0)
- UniProt
- Q15758
- Ligands
- NAG
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 66% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Neutral amino acid transporter B(0) | protein | 446 | 66% helix, 3% strand | Q15758 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1029 | 0.86 | 0.86 | 46 | empty |
| 2 | 912 | 0.75 | 0.79 | 92 | empty |
| 3 | 781 | 0.71 | 0.77 | 71 | empty |
| 4 | 249 | 0.70 | 0.86 | 31 | empty |
| 5 | 620 | 0.69 | 0.78 | 69 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1567 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 1477 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1454 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 glycan (N-glycosylation).
Compared structures
- 6MP6 · Cryo-EM structure of the human neutral amino acid transporter ASCT2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q15758 · AlphaFold monomer V2.0 prediction for neutral amino acid transporter B(0) (Q15758) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15758
- Elsewhere: RCSB PDB 6MP6 · PDBe 6MP6 · UniProt Q15758
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