MolNFT v1 · #125876 · protein

Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-asp and the allosteric inhibitor UCPH101

5LM4: “Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-asp and the allosteric inhibitor…”. X-ray diffraction, 2 ligands (6Z6, NA). MolNFT v1 #125876 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LM4
Type: protein
Length: 390 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P43003, Q15758
Ligands: 6Z6, NA

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	390	—	P43003, Q15758

Ligands and binding sites

6Z6 · 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile · ligand · chains A
NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5LM4 · Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-ASP and the… · the same entry in another collection · chain A against A, TM-score 1.00
P43003 · AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 1 (P43003) · a predicted model of the same protein · chain A against A, TM-score 0.97
Q15758 · AlphaFold monomer V2.0 prediction for neutral amino acid transporter B(0) (Q15758) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43003
Every structure of UniProt Q15758
Elsewhere: RCSB PDB 5LM4 · PDBe 5LM4 · UniProt P43003 · UniProt Q15758

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