UniProt P43003
Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1 (P43003)
Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1 (UniProt P43003): 13 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 8 pockets. Binding…
- UniProt
- P43003
- Protein
- Excitatory amino acid transporter 1,Neutral amino acid transporter…
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 8 · 2 records with a druggable one
Structures
14 records of P43003 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LLM | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-ASP and the allosteric… | x-ray diffraction | A | NA, ASP, 6Z6 | 4 (best 0.69) |
| 5LLM | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-asp and the allosteric… | x-ray diffraction | A | NA, 6Z6 | — |
| 5LLU | Structure of the thermostabilized EAAT1 cryst-II mutant in complex with L-ASP | x-ray diffraction | A | NA, ASP | 4 (best 0.65) |
| 5LLU | Structure of the thermostabilized EAAT1 cryst-II mutant in complex with L-asp | x-ray diffraction | A | NA | — |
| 5LM4 | Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-ASP and the allosteric… | x-ray diffraction | A | NA, 6Z6 | — |
| 5LM4 | Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-asp and the allosteric… | x-ray diffraction | A | NA, 6Z6 | — |
| 5MJU | Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor… | x-ray diffraction | A | 6Z6, 7O9 | — |
| 5MJU | Structure of the thermostabilized EAAT1 cryst mutant in complex with the competititve inhibitor… | x-ray diffraction | A | 6Z6, 7O9 | — |
| 7AWM | Structure of the thermostabilized EAAT1 cryst mutant in complex with L-asp, three sodium ions and… | x-ray diffraction | A | NA, 6Z6 | — |
| 7AWN | Structure of the thermostabilized EAAT1 cryst mutant in complex with rubidium and barium and the… | x-ray diffraction | A | 6Z6, BA, RB | — |
| 7AWP | Structure of the thermostabilized EAAT1 cryst-II mutant in complex with rubidium and barium ions… | x-ray diffraction | A | 6Z6, BA, RB | — |
| 7AWQ | Structure of the thermostabilized EAAT1 cryst-E386Q mutant in complex with L-asp, sodium ions and… | x-ray diffraction | A | NA, 6Z6, BA | — |
| 7NPW | Cryo-EM structure of human excitatory amino acid transporters-1 (EAAT1) in potassium buffer | electron microscopy | A, B, C | — | — |
| P43003 | AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 1 (P43003) | predicted | A | — | — |
Ligands
- 6Z6 · 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile · in 10 records
- NA · Sodium ion · in 8 records
- BA · Barium ion · in 3 records
- 7O9 · (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl) phenyl]carbonylamino]phenyl]methoxy]butanedioic acid · in 2 records
- ASP · Aspartic acid · in 2 records
- RB · Rubidium ion · in 2 records
Experiment against prediction
- 5LLU chain A against the predicted model P43003: TM-score 0.97, RMSD 1.35 Å
- 5LLU chain A against the predicted model P43003: TM-score 0.97, RMSD 1.35 Å
- 5LM4 chain A against the predicted model P43003: TM-score 0.97, RMSD 1.34 Å
- 5LM4 chain A against the predicted model P43003: TM-score 0.97, RMSD 1.34 Å
- 5LLM chain A against the predicted model P43003: TM-score 0.96, RMSD 1.63 Å
- 5LLM chain A against the predicted model P43003: TM-score 0.96, RMSD 1.49 Å
- 7AWN chain A against the predicted model P43003: TM-score 0.96, RMSD 1.61 Å
- 7AWQ chain A against the predicted model P43003: TM-score 0.96, RMSD 1.80 Å
- 7AWM chain A against the predicted model P43003: TM-score 0.96, RMSD 1.91 Å
- 7AWP chain A against the predicted model P43003: TM-score 0.96, RMSD 1.61 Å
Elsewhere
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