MolNFT v1 · #163208 · protein
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate
6RVY · Neutral amino acid transporter B(0): “Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #163208 on GenesisL1: 3D structure, binding…
- PDB
- 6RVY
- Type
- protein
- Length
- 1,290 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neutral amino acid transporter B(0)
- UniProt
- Q15758
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 70% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Neutral amino acid transporter B(0) | protein | 430 | 70% helix, 4% strand | Q15758 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1066 | 0.86 | 0.86 | 44 | empty |
| 2 | 501 | 0.72 | 0.81 | 49 | empty |
| 3 | 474 | 0.72 | 0.81 | 46 | empty |
| 4 | 463 | 0.71 | 0.81 | 46 | empty |
| 5 | 426 | 0.65 | 0.78 | 51 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1427 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 1426 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1423 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6RVY · Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate · the same entry in another collection · chain A against A, TM-score 1.00
- Q15758 · AlphaFold monomer V2.0 prediction for neutral amino acid transporter B(0) (Q15758) · a predicted model of the same protein · chain B against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15758
- Elsewhere: RCSB PDB 6RVY · PDBe 6RVY · UniProt Q15758
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